We have demonstrated antibacterial activity of dendritic Fe3O4 magnetic nanoadsorbents (DMNA) against Gram positive (S. aureus, B. subtilis) and Gram negative (E. coli, P. aeruginosa) bacteria. These nanoadsorbents were nearly spherical with an average diameter 10 nm showed superparamagnetic behavior at room temperature with strong field dependent magnetic responsivity. The magnetic nanoadsorbents having terminal amino acids on the shell create exteriors functionalities with high densities of organic moieties (both amine and carboxyl) for capturing of various microorganisms. Depending upon the surface functionality, DMNA has strong antibacterial activity (similar to 97% killing efficiency) towards S. aureus even at very low concentration. In addition, these nanoadsorbents can be used as most efficient, separable and reusable materials for killing bacterial pathogens.
机构:
Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Chandra, Sudeshna
;
Mehta, Shailee
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Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Mehta, Shailee
;
Nigam, Saumya
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Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Nigam, Saumya
;
Bahadur, D.
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Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
机构:
Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Chertok, Beata
;
Moffat, Bradford A.
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Univ Michigan, Sch Med, Ctr Mol Imaging, Dept Radiol, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Moffat, Bradford A.
;
David, Allan E.
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Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
David, Allan E.
;
Yu, Faquan
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Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Yu, Faquan
;
Bergemann, Christian
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Chemicell GmbH, D-10823 Berlin, GermanyUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Bergemann, Christian
;
Ross, Brian D.
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Univ Michigan, Sch Med, Ctr Mol Imaging, Dept Radiol, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Ross, Brian D.
;
Yang, Victor C.
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机构:
Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Tianjin Univ, Sch Chem Engn, Tianjin 300072, Peoples R ChinaUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
机构:
Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Chandra, Sudeshna
;
Mehta, Shailee
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机构:
Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Mehta, Shailee
;
Nigam, Saumya
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机构:
Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Nigam, Saumya
;
Bahadur, D.
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机构:
Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
机构:
Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Chertok, Beata
;
Moffat, Bradford A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Ctr Mol Imaging, Dept Radiol, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Moffat, Bradford A.
;
David, Allan E.
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h-index: 0
机构:
Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
David, Allan E.
;
Yu, Faquan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Yu, Faquan
;
Bergemann, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Chemicell GmbH, D-10823 Berlin, GermanyUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Bergemann, Christian
;
Ross, Brian D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Ctr Mol Imaging, Dept Radiol, Ann Arbor, MI 48109 USAUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Ross, Brian D.
;
Yang, Victor C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
Tianjin Univ, Sch Chem Engn, Tianjin 300072, Peoples R ChinaUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA