Pancreatic Cancer Therapy Review: From Classic Therapeutic Agents to Modern Nanotechnologies

被引：23

作者：

Rebelo, Ana ^{[1
]}

Molpeceres, Jesus ^{[2
]}

Rijo, Patricia ^{[1
,3
]}

Reis, Catarina Pinto ^{[1
,4
]}

机构：

[1] Univ Lusofona Humanidades & Tecnol, CBIOS, Campo Grande 376, P-1749024 Lisbon, Portugal

[2] Univ Alcala De Henares, Fac Pharm, Dept Biomed Sci, Ctra A2km 33,600 Campus Univ, Alcala De Henares 28871, Spain

[3] Univ Lisbon, iMed ULisboa, Fac Farm, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal

[4] Univ Lisbon, Fac Ciencias, IBEB, P-1749016 Lisbon, Portugal

来源：

CURRENT DRUG METABOLISM | 2017年 / 18卷 / 04期

关键词：

Pancreatic cancer; nanoparticles; targeted therapy; polymers; drug delivery; signaling pathways; PROTEIN-TYROSINE KINASES; IN-VITRO EVALUATION; TARGETED NANOPARTICLES; MAGNETIC NANOPARTICLES; ALBUMIN NANOPARTICLES; MOLECULAR PATHWAYS; WHOLE-EXOME; GEMCITABINE; RECEPTOR; PROGRESSION;

D O I：

10.2174/1389200218666170201151135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pancreatic cancer remains one of the most lethal cancers worldwide, with an extremely poor prognosis. This cancer is considered the 5th leading cause of cancer related death. The median survival after diagnosis is generally 2-8 months and five-year survival rate is less than 5%. In recent years, nanotechnology is emerging as a rising approach for drug delivery since it has opened up new landscapes in medicine through introduction of smart nanocarrier systems that can selectively deliver the therapeutic agent in a specific region and in appropriate levels, reducing the adverse side effects. This review covers the main delivery systems developed so far for anticancer drug delivery to the pancreas over a period of 20 years, from polymeric to lipidic-based nanosystems, with a particular emphasis on albumin as core material.

引用

页码：346 / 359

页数：14

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