Distribution of mercury in serum and blood cells and risk of spontaneous preterm birth: A nested case-control study in China

被引：6
作者：
An, Hang [1 ,2 ]
Wang, Bin [1 ,2 ]
Li, Zhiyi [3 ]
Jin, Yu [1 ,2 ]
Ren, Mengyuan [1 ,2 ]
Yu, Yanxin [4 ]
Zhang, Yali [1 ,2 ]
Zhang, Le [1 ,2 ]
Yan, Lailai [5 ]
Li, Zhiwen [1 ,2 ]
Ren, Aiguo [1 ,2 ]
Ye, Rongwei [1 ,2 ]
Li, Kexin [3 ]
机构：
[1] Peking Univ, Key Lab Reprod Hlth, Natl Hlth Commiss Peoples Republ China, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China
[2] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
[3] Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
[4] Beijing Normal Univ, Sch Environm, Beijing 100875, Peoples R China
[5] Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing 100191, Peoples R China
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2021年 / 217卷
基金：
中国国家自然科学基金;
关键词：
Mercury; Spontaneous preterm birth; Serum; Blood cell; METHYL MERCURY; WHOLE-BLOOD; PREGNANT-WOMEN; HEAVY-METALS; EXPOSURE; PLASMA; FISH; LEAD; ASSOCIATION; CADMIUM;
D O I：
10.1016/j.ecoenv.2021.112228
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The relationship between maternal mercury (Hg) intake and the risk of spontaneous preterm birth (SPB) remains unclear. We conducted a nested case-control study from a prospective cohort in Shanxi Province, China, to explore their associations. In total, 126 pregnant women with SPB (cases) and 348 controls with term delivery were included. We measured the Hg concentrations in their serum (Hgs) and blood cell (Hgc) fractions and calculated the concentration ratio of Hg in serum to Hg in blood cells (Hgs/c). We found that only the Hgs/c in the case group was slightly higher than that in control group. The OR of Hgs/c associated with SPB risk was 1.57 [95%CI: 0.99-2.46] with adjusting confounders. After stratification by sampling time, the association above was only statistically significant in the first trimester. High Hgs/c may increase the risk of SPB in the first trimester among women with relatively low Hg exposure.
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