Molecular-Genetic Imaging of Cancer

被引：16

作者：

Minn, Il ^{[1
]}

Menezes, Mitchell E. ^{[2
]}

Sarkar, Siddik ^{[2
]}

Yarlagadda, Keerthi ^{[1
]}

Das, Swadesh K. ^{[2
,3
]}

Emdad, Luni ^{[2
,3
,4
]}

Sarkar, Devanand ^{[2
,3
,4
]}

Fisher, Paul B. ^{[2
,3
,4
]}

Pomper, Martin G. ^{[1
,5
]}

机构：

[1] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21218 USA

[2] Dept Human & Mol Genet, Richmond, VA USA

[3] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Richmond, VA USA

[4] Virginia Commonwealth Univ, Sch Med, VCU Massey Canc Ctr, Richmond, VA USA

[5] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

来源：

EMERGING APPLICATIONS OF MOLECULAR IMAGING TO ONCOLOGY | 2014年 / 124卷

关键词：

2-STEP TRANSCRIPTIONAL AMPLIFICATION; IN-VIVO; MEMBRANE ANTIGEN; PLASMID DNA; TRANSGENE EXPRESSION; REPORTER GENE; PAMAM DENDRIMERS; PROSTATE-CANCER; MESSENGER-RNA; INTRAMUSCULAR INJECTION;

D O I：

10.1016/B978-0-12-411638-2.00004-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization of various cellular processes including detection of cancer, and its attendant metastases. In recent years, significant effort has been expended in overcoming technical hurdles to enable clinical adoption of molecular-genetic imaging. This chapter will provide an introduction to the components of molecular-genetic imaging and recent advances on each component leading to safe, efficient clinical applications for detecting cancer. Combination with therapy, namely, generating molecular-genetic theranostic constructs, will provide further impetus for clinical translation of this promising technology.

引用

页码：131 / 169

页数：39

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