Synthesis of dimethyl 1,2-dihydroisoquinolines through the reaction of isoquinoline and dimethyl acetylenedicarboxylate in the presence of amides

被引：52

作者：

Yavari, Issa ^{[1
]}

Ghazanfarpour-Darjani, Majid ^{[1
]}

Sabbaghan, Maryam ^{[1
]}

Hossaini, Zinatossadat ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 21期

关键词：

aminals; amide; quinoline; isoquinoline; acetylenic ester;

D O I：

10.1016/j.tetlet.2007.03.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isoquinoline reacts smoothly with dimethyl acetylenedicarboxylate (DMAD) in the presence of amides to produce dimethyl 2-[1-[aryl(alkyl)carbonylamino]-2(1H)-isoquinolinyl]-2-butenedioates. Reaction of quinoline with DMAD in the presence of benzamide led to dimethyl 2-[1-[(phenylcarbonyl)amino]-2(1 H)-quinolinyl]-2-butenedioate. (c) 2007 Published by Elsevier Ltd.

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收藏

页码：3749 / 3751

页数：3

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