Oxytetracycline Inhibits Mucus Secretion and Inflammation in Human Airway Epithelial Cells

被引：6

作者：

Shah, Said Ahmad ^{[1
]}

Ishinaga, Hajime ^{[1
]}

Takeuchi, Kazuhiko ^{[1
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Otorhinolaryngol Head & Neck Surg, 2-174 Edobashi, Tsu, Mie 5148507, Japan

来源：

CHEMOTHERAPY | 2017年 / 62卷 / 05期

关键词：

Oxytetracycline; MUC5AC gene; IL-8; IL-1; beta; Anti-inflammatory effect; PULMONARY INFLAMMATION; GENE-EXPRESSION; COPD PATIENTS; MUCIN; LUNG;

D O I：

10.1159/000475983

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oxytetracycline is a broad-spectrum antibiotic, but its non-antibacterial effects in the human respiratory tract are unknown. In this study, the effects of oxytetracycline on mucus secretion and inflammation were examined by PCR and ELISA in the human airway epithelial cell line NCI-H292. Oxytetracycline (10 mu g/mL) significantly inhibited TNF-alpha-induced MUC5AC gene expression and MUC5AC protein levels in NCIH292 cells. It also downregulated IL-8 and IL-1 beta gene expression and IL-1 beta protein levels. Our findings demonstrated that oxytetracycline suppressed mucus production and inflammation in human respiratory epithelial cells, providing further evidence for the usefulness of oxytetracycline for human airway inflammatory diseases. (C) 2017 S. Karger AG, Basel

引用

收藏

页码：301 / 306

页数：6

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