Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats

被引：20
作者：
Xi, Jiancheng [1 ]
Luo, Xiaobo [1 ]
Wang, Yipeng [1 ]
Li, Jinglong [1 ]
Guo, Lixin [1 ]
Wu, Guangseng [1 ]
Li, Qingui [1 ]
机构：
[1] 309th Hosp Peoples Liberat Army, Dept Minimally Invas Spine Surg, 17 Montenegro Jhao Rd, Beijing 100091, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2019年 / 18卷 / 05期
关键词：
tetrahydrocurcumin; spinal cord injury; oxidative stress; forkhead box O; GLIAL SCAR FORMATION; MATRIX METALLOPROTEINASES; INFLAMMATION; PERFORMANCE; ACTIVATION; APOPTOSIS; PATHWAY; PEOPLE; MUSCLE;
D O I：
10.3892/etm.2019.7974
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
It has been reported that tetrahydrocurcumin has hypoglycemic, hypolipidemic, anti-metastasis, anticancer and anti-depressant pharmacological effects, and its antioxidative, hypoglycemic and hypolipidemic properties are better than those of curcumin. The present study assessed whether tetrahydrocurcumin exerts a neuroprotective effect against spinal cord injury (SCI) and investigated the underlying mechanisms. In a rat model of SCI, tetrahydrocurcumin enhanced the average Basso-Beattie-Bresnahan scores, inhibited water accumulation in the spinal cord and decreased inflammatory factors. Furthermore, oxidative stress and apoptosis (caspase-3 activity and B-cell lymphoma 2-associated X protein levels) were also suppressed in SCI rats treated with tetrahydrocurcumin. Tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase-3 and -13, as well as cyclooxygenase-2, promoted the phosphorylation of Akt and enhanced the protein expression of forkhead box (FOX)O4 in SCI rats. The present study delineates that tetrahydrocurcumin protects against SCI and inhibits the oxidative stress response by regulating the FOXO4 in SCI model rats.
引用
收藏
页码：3681 / 3687
页数：7
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