Transgenerational transmission of environmental information in C-elegans

被引：269

作者：

Klosin, Adam ^{[1
,2
]}

Casas, Eduard ^{[3
]}

Hidalgo-Carcedo, Cristina ^{[1
,2
]}

Vavouri, Tanya ^{[3
,4
]}

Lehner, Ben ^{[1
,2
,5
]}

机构：

[1] European Mol Biol Org, EMBL CRG Syst Biol Unit, Ctr Genom Regulat, Barcelona 08003, Spain

[2] Univ Pompeu Fabra, Barcelona 08003, Spain

[3] Inst Germans Trias & Pujol, Program Predict & Personalized Med Canc, Campus Can Ruti, Barcelona 08916, Spain

[4] Josep Carreras Leukaemia Res Inst, Barcelona 08916, Spain

[5] Inst Catalana Recerca & Estudis Avancats, Barcelona 08010, Spain

来源：

SCIENCE | 2017年 / 356卷 / 6335期

基金：

欧洲研究理事会;

关键词：

IN-UTERO UNDERNUTRITION; CAENORHABDITIS-ELEGANS; EPIGENETIC INHERITANCE; GERMLINE; METHYLATION; OBESITY; DIET; STARVATION; RESISTANCE; MAMMALS;

D O I：

10.1126/science.aah6412

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The environment experienced by an animal can sometimes influence gene expression for one or a few subsequent generations. Here, we report the observation that a temperature-induced change in expression from a Caenorhabditis elegans heterochromatic gene array can endure for at least 14 generations. Inheritance is primarily in cis with the locus, occurs through both oocytes and sperm, and is associated with altered trimethylation of histone H3 lysine 9 (H3K9me3) before the onset of zygotic transcription. Expression profiling reveals that temperature-induced expression from endogenous repressed repeats can also be inherited for multiple generations. Long-lasting epigenetic memory of environmental change is therefore possible in this animal.

引用

收藏

页码：316 / 319

页数：4

相关论文

共 25 条

[1] piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans [J].

Ashe, Alyson ;

Sapetschnig, Alexandra ;

Weick, Eva-Maria ;

Mitchell, Jacinth ;

Bagijn, Marloes P. ;

Cording, Amy C. ;

Doebley, Anna-Lisa ;

Goldstein, Leonard D. ;

Lehrbach, Nicolas J. ;

Le Pen, Jeremie ;

Pintacuda, Greta ;

Sakaguchi, Aisa ;

Sarkies, Peter ;

Ahmed, Shawn ;

Miska, Eric A. .

CELL, 2012, 150 (01) :88-99

[2] Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance [J].

Berry, Scott ;

Hartley, Matthew ;

Olsson, Tjelvar S. G. ;

Dean, Caroline ;

Howard, Martin .

[3] A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality [J].

Buckley, Bethany A. ;

Burkhart, Kirk B. ;

Gu, Sam Guoping ;

Spracklin, George ;

Kershner, Aaron ;

Fritz, Heidi ;

Kimble, Judith ;

Fire, Andrew ;

Kennedy, Scott .

NATURE, 2012, 489 (7416) :447-451

[4] Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals [J].

Carone, Benjamin R. ;

Fauquier, Lucas ;

Habib, Naomi ;

Shea, Jeremy M. ;

Hart, Caroline E. ;

Li, Ruowang ;

Bock, Christoph ;

Li, Chengjian ;

Gu, Hongcang ;

Zamore, Phillip D. ;

Meissner, Alexander ;

Weng, Zhiping ;

Hofmann, Hans A. ;

Friedman, Nir ;

Rando, Oliver J. .

CELL, 2010, 143 (07) :1084-1096

[5] Understanding transgenerational epigenetic inheritance via the gametes in mammals [J].

Daxinger, Lucia ;

Whitelaw, Emma .

NATURE REVIEWS GENETICS, 2012, 13 (03) :153-162

[6] Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint [J].

Gu, Sam Guoping ;

Pak, Julia ;

Guang, Shouhong ;

Maniar, Jay M. ;

Kennedy, Scott ;

Fire, Andrew .

NATURE GENETICS, 2012, 44 (02) :157-164

[7] Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine [J].

Hackett, Jamie A. ;

Sengupta, Roopsha ;

Zylicz, Jan J. ;

Murakami, Kazuhiro ;

Lee, Caroline ;

Down, Thomas A. ;

Surani, M. Azim .

SCIENCE, 2013, 339 (6118) :448-452

[8] Epigenetic germline inheritance of diet-induced obesity and insulin resistance [J].

Huypens, Peter ;

Sass, Steffen ;

Wu, Moya ;

Dyckhoff, Daniela ;

Tschoep, Matthias ;

Theis, Fabian ;

Marschall, Susan ;

de Angelis, Martin Hrabe ;

Beckers, Johannes .

NATURE GENETICS, 2016, 48 (05) :497-+

[9] Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice [J].

Jimenez-Chillaron, Josep C. ;

Isganaitis, Elvira ;

Charalambous, Marika ;

Gesta, Stephane ;

Pentinat-Pelegrin, Thais ;

Faucette, Ryan R. ;

Otis, Jessica P. ;

Chow, Alice ;

Diaz, Ruben ;

Ferguson-Smith, Anne ;

Patti, Mary-Elizabeth .

DIABETES, 2009, 58 (02) :460-468

[10] Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans [J].

Jobson, Meghan A. ;

Jordan, James M. ;

Sandrof, Moses A. ;

Hibshman, Jonathan D. ;

Lennox, Ashley L. ;

Baugh, L. Ryan .

GENETICS, 2015, 201 (01) :201-+