Chemical constituents from Baphia leptobotrys Harms (Fabaceae) and their chemophenetic significance

被引：9

作者：

Wonkam, Argan Kelly Nkwenti ^{[1
,2
]}

Ngansop, Cyrille Armel Njanpa ^{[3
]}

Tchuenmogne, Marthe Aimee Tchuente ^{[4
]}

Tchegnitegni, Billy Toussie ^{[4
]}

Bitchagno, Gabin Thierry Mbahbou ^{[4
]}

Awantu, Angelbert Fusi ^{[5
]}

Bankeu, Jean Jules Kezetas ^{[5
]}

Boyom, Fabrice Fekam ^{[3
]}

Sewald, Norbert ^{[6
]}

Lenta, Bruno Ndjakou ^{[1
]}

机构：

[1] Univ Yaounde I, Dept Chem, Higher Teacher Training Coll, POB 47, Yaounde, Cameroon

[2] Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon

[3] Univ Yaounde I, Dept Biochem, Fac Sci, POB 812, Yaounde, Cameroon

[4] Univ Dschang, Fac Sci, Dept Chem, POB 67, Dschang, Cameroon

[5] Univ Bamenda, Fac Sci, Dept Chem, POB 39, Bambili, Cameroon

[6] Bielefeld Univ, Fac Chem, Organ & Bioorgan Chem, D-33501 Bielefeld, Germany

来源：

BIOCHEMICAL SYSTEMATICS AND ECOLOGY | 2021年 / 96卷

关键词：

Baphia leptobotrys; Fabaceae; Chemophenetic significance; Antileishmanial activity; Cytotoxicity; TRITERPENES; TERPENOIDS; GROWTH; LIPIDS;

D O I：

10.1016/j.bse.2021.104260

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical investigation of the CH2Cl2/MeOH (1:1) extract of the trunk bark and leaves of Baphia leptobotrys Harms (Fabaceae) led to the isolation of nineteen compounds (1-19). Their structures were elucidated based on the analysis of their NMR and MS data. Except for compounds 3-5, 14 and 15, all the isolated compounds are reported from the genus Baphia for the first time. Furthermore, compounds 8, 10, 16, 17 are isolated from the Fabaceae family for the first time. The crude extract and isolated compounds were screened in vitro for their antileishmanial activity against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes and cytotoxicity towards Raw 264.7 macrophage cells. The crude extract of B. leptobotrys exhibited moderate activity (IC50 = 63.40 mu g/mL). Amongst the tested compounds, ergosterol peroxide (9) and germanicol caffeoyl ester (8) exhibited good activity with IC50 values of 9.43 and 10.24 mu M, respectively and showed acceptable selectivity towards macrophage cells (SI > 3.85). The chemophenetic significance of these compounds is also discussed.

引用

页数：6

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