The efficacy and safety of probiotics intervention in attenuating cardiac remodeling following myocardial infraction: Literature review and study protocol for a randomized, double-blinded, placebo controlled trial

被引:21
作者
Moludi, Jalal [1 ,2 ]
Alizadeh, Mohammad [1 ]
Davari, Mina [1 ]
Golmohammadi, Ali [3 ]
Maleki, Vahid [1 ]
机构
[1] Tabriz Univ Med Sci, Fac Nutr, Nutr Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran
关键词
Cardiac remodeling; Heart failure; Microbiome; Myocardial infraction; Probiotics; TRIMETHYLAMINE-N-OXIDE; SWEET-POTATO YOGURT; QUALITY-OF-LIFE; HEART-FAILURE; GUT MICROBIOTA; CARDIOVASCULAR-DISEASE; METABOLIC ENDOTOXEMIA; SYSTEMIC INFLAMMATION; INFARCTION; SURVIVAL;
D O I
10.1016/j.conctc.2019.100364
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Introduction: Structural and functional changes that occur post myocardial infraction (MI) lead to the syndrome of heart failure (HF). However, their pathogenesis is poorly understood. Recently, alteration of the intestinal microbiota (dysbiosis) has emerged as a new candidate that may be correlated with risk of HF development. We hypothesized that selective gut modulation by probiotic administration may improve metabolic dysfunction and attenuate cardiac remodeling (CR) in MI subjects. Methods: /Design: This article is presented in two sections: First, we provided a review of recent findings related to gut microbiota and CR and their association with probiotic supplementation. Secondly, we will conduct a randomized double-blinded controlled clinical trial in 46 Iranian patients with MI after successful percutaneous coronary intervention (PCI). The participants (age: >= 30 years; ejection fraction (EF) greater than 30) will be selected by a simple random sampling method and will be assigned to 3 months of 1.6* 10(9) CFU probiotic (Lactobacillus rhamnosus), or placebo groups (maltodextrin). The primary outcome is development of CR. The secondary outcomes measures include gut microbiota profile, biochemical variables and the safety of the probiotics supplementation. Also, echocardiography will be measured at baseline and following treatment. The data will be compared within and between groups using appropriate statistical methods. Discussion: The results of this trial will provide evidence about the efficacy and safety of gut microbiota manipulation by probiotics in post-MI cardiac remodeling prevention.
引用
收藏
页数:7
相关论文
共 50 条
[1]   Probiotic Supplementation and Trimethylamine-N-Oxide Production Following a High-Fat Diet [J].
Boutagy, Nabil E. ;
Neilson, Andrew P. ;
Osterberg, Kristin L. ;
Smithson, Andrew T. ;
Englund, Tessa R. ;
Davy, Brenda M. ;
Hulver, Matthew W. ;
Davy, Kevin P. .
OBESITY, 2015, 23 (12) :2357-2363
[2]   Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice [J].
Cani, Patrice D. ;
Bibiloni, Rodrigo ;
Knauf, Claude ;
Neyrinck, Audrey M. ;
Neyrinck, Audrey M. ;
Delzenne, Nathalle M. ;
Burcelin, Remy .
DIABETES, 2008, 57 (06) :1470-1481
[3]   Correlates of Echocardiographic Indices of Cardiac Remodeling Over the Adult Life Course Longitudinal Observations From the Framingham Heart Study [J].
Cheng, Susan ;
Xanthakis, Vanessa ;
Sullivan, Lisa M. ;
Lieb, Wolfgang ;
Massaro, Joseph ;
Aragam, Jayashri ;
Benjamin, Emelia J. ;
Vasan, Ramachandran S. .
CIRCULATION, 2010, 122 (06) :570-U37
[4]   Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction [J].
Chow, JC ;
Young, DW ;
Golenbock, DT ;
Christ, WJ ;
Gusovsky, F .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10689-10692
[5]   Cardiac remodeling-concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling [J].
Cohn, JN ;
Ferrari, R ;
Sharpe, N .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (03) :569-582
[6]  
Collins MD, 1999, AM J CLIN NUTR, V69, p1052S, DOI 10.1093/ajcn/69.5.1052s
[7]   Probiotic therapy with Saccharomyces boulardii for heart failure patients: A randomized, double-blind, placebo-controlled pilot trial [J].
Costanza, Annelise C. ;
Moscavitch, Samuel D. ;
Faria Neto, Hugo C. C. ;
Mesquita, Evandro T. .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2015, 179 :348-350
[8]   C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease [J].
Danesh, J ;
Wheeler, JG ;
Hirschfield, GM ;
Eda, S ;
Eiriksdottir, G ;
Rumley, A ;
Lowe, GDO ;
Pepys, MB ;
Gudnason, V .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (14) :1387-1397
[9]   Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial [J].
Dehghan, Parvin ;
Gargari, Bahram Pourghassem ;
Jafar-Abadi, Mohammad Asghari ;
Aliasgharzadeh, Akbar .
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2014, 65 (01) :117-123
[10]  
DRACUP K, 1992, J HEART LUNG TRANSPL, V11, P273