Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA

被引：224

作者：

van der Pol, Ymke ^{[1
]}

Mouliere, Florent ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Dept Pathol, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

来源：

CANCER CELL | 2019年 / 36卷 / 04期

关键词：

CIRCULATING TUMOR DNA; LIQUID BIOPSIES; PLASMA DNA; LUNG-CANCER; MITOCHONDRIAL-DNA; 5-HYDROXYMETHYLCYTOSINE SIGNATURES; PERSONALIZED MEDICINE; NONINVASIVE DETECTION; STRANDED-DNA; METHYLATION;

D O I：

10.1016/j.ccell.2019.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic alterations, but only a minor fraction of tumor-derived cell-free DNA (cfDNA) fragments exhibit mutations. The cellular processes occurring in cancer development mark the chromatin. These epigenetic marks are reflected by modifications in the cfDNA methylation, fragment size, and structure. In this review, we describe how going beyond DNA sequence information alone, by analyzing cfDNA epigenetic and immune signatures, boosts the potential of liquid biopsy for the early detection of cancer.

引用

页码：350 / 368

页数：19

共 50 条

[41] Cell-free circulating tumor DNA in cancer [J].

Qin, Zhen ;

Ljubimov, Vladimir A. ;

Zhou, Cuiqi ;

Tong, Yunguang ;

Liang, Jimin .

CHINESE JOURNAL OF CANCER, 2016, 35

[42] Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification [J].

Liu, L. ;

Toung, J. M. ;

Jassowicz, A. F. ;

Vijayaraghavan, R. ;

Kang, H. ;

Zhang, R. ;

Kruglyak, K. M. ;

Huang, H. J. ;

Hinoue, T. ;

Shen, H. ;

Salathia, N. S. ;

Hong, D. S. ;

Naing, A. ;

Subbiah, V. ;

Piha-Paul, S. A. ;

Bibikova, M. ;

Granger, G. ;

Barnes, B. ;

Shen, R. ;

Gutekunst, K. ;

Fu, S. ;

Tsimberidou, A. M. ;

Lu, C. ;

Eng, C. ;

Moulder, S. L. ;

Kopetz, E. S. ;

Amaria, R. N. ;

Meric-Bernstam, F. ;

Laird, P. W. ;

Fan, J. -B. ;

Janku, F. .

ANNALS OF ONCOLOGY, 2018, 29 (06) :1445-1453

[43] Tissue and Cell-Free DNA-Based Epigenomic Approaches for Cancer Detection [J].

Leal, Alessandro ;

Sidransky, David ;

Brait, Mariana .

CLINICAL CHEMISTRY, 2020, 66 (01) :105-116

[44] The Potential of Cell-Free DNA in Cancer: towards Standardization and Optimization for Enhanced Diagnosis and Monitoring [J].

Khurram, Iqra ;

Khan, Muhammad Umer ;

Saleem, Ayman ;

Ibrahim, Saooda ;

Ghani, Muhammad Usman ;

Shahid, Muhammad ;

Amin, Iram ;

Calina, Daniela ;

Sharifi-Rad, Javad .

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2024, 38 (04) :2713-2732

[45] Liquid biopsies based on cell-free DNA as a potential biomarker in head and neck cancer [J].

Rapado-Gonzalez, Oscar ;

Rodriguez-Ces, Ana Maria ;

Lopez-Lopez, Rafael ;

Suarez-Cunqueiro, Maria Mercedes .

JAPANESE DENTAL SCIENCE REVIEW, 2023, 59 :289-302

[46] Multimodal epigenetic sequencing analysis (MESA) of cell-free DNA for non-invasive colorectal cancer detection [J].

Li, Yumei ;

Xu, Jianfeng ;

Chen, Chaorong ;

Lu, Zhenhai ;

Wan, Desen ;

Li, Diange ;

Li, Jason S. ;

Sorg, Allison J. ;

Roberts, Curt C. ;

Mahajan, Shivani ;

Gallant, Maxime A. ;

Pinkoviezky, Itai ;

Cui, Ya ;

Taggart, David J. ;

Li, Wei .

GENOME MEDICINE, 2024, 16 (01)

[47] Epigenetic phenotype of plasma cell-free DNA in the prediction of early-onset preeclampsia [J].

He, Wei ;

Zhang, Yi ;

Wu, Kai ;

Wang, Yunan ;

Zhao, Xin ;

Lv, Lijuan ;

Ren, Congmian ;

Lu, Jiaqi ;

Yang, Jiexia ;

Yin, Aihua ;

Liu, Guocheng .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2023, 43 (02)

[48] Multidimensional Cell-Free DNA Fragmentomic Assay for Detection of Early-Stage Lung Cancer [J].

Wang, Siwei ;

Meng, Fanchen ;

Li, Ming ;

Bao, Hua ;

Chen, Xin ;

Zhu, Meng ;

Liu, Rui ;

Xu, Xiuxiu ;

Yang, Shanshan ;

Wu, Xue ;

Shao, Yang ;

Xu, Lin ;

Yin, Rong .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207 (09) :1203-1213

[49] Epigenomic Blood-Based Early Detection of Pancreatic Cancer Employing Cell-Free DNA [J].

Haan, David ;

Bergamaschi, Anna ;

Friedl, Verena ;

Guler, Gulfem D. ;

Ning, Yuhong ;

Reggiardo, Roman ;

Kesling, Michael ;

Collins, Micah ;

Gibb, Bill ;

Hazen, Kyle ;

Bates, Steve ;

Antoine, Michael ;

Fraire, Carolina ;

Lopez, Vanessa ;

Malta, Roger ;

Nabiyouni, Maryam ;

Nguyen, Albert ;

Phillips, Tierney ;

Riviere, Michael ;

Leighton, Anna ;

Ellison, Christopher ;

McCarthy, Erin ;

Scott, Aaron ;

Gigliotti, Lauren ;

Nilson, Eric ;

Sheard, Judith ;

Peters, Melissa ;

Bethel, Kelly ;

Chowdhury, Shimul ;

Volkmuth, Wayne ;

Levy, Samuel .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2023, 21 (07) :1802-+

[50] Cell-Free DNA (cfDNA) Methylation Assay Allows for Early Detection and Identification of Lung Cancer [J].

Kruusmaa, K. ;

Bitenc, M. ;

Chersicola, M. ;

Weinhaeusel, A. ;

Pulverer, W. .

JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) :S491-S491

← 1 2 3 4 5 →