Toward the Early Detection of Cancer by Decoding the Epigenetic and Environmental Fingerprints of Cell-Free DNA

被引：224

作者：

van der Pol, Ymke ^{[1
]}

Mouliere, Florent ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Canc Ctr Amsterdam, Dept Pathol, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

来源：

CANCER CELL | 2019年 / 36卷 / 04期

关键词：

CIRCULATING TUMOR DNA; LIQUID BIOPSIES; PLASMA DNA; LUNG-CANCER; MITOCHONDRIAL-DNA; 5-HYDROXYMETHYLCYTOSINE SIGNATURES; PERSONALIZED MEDICINE; NONINVASIVE DETECTION; STRANDED-DNA; METHYLATION;

D O I：

10.1016/j.ccell.2019.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Widespread adaptation of liquid biopsy for the early detection of cancer has yet to reach clinical utility. Circulating tumor DNA is commonly detected though the presence of genetic alterations, but only a minor fraction of tumor-derived cell-free DNA (cfDNA) fragments exhibit mutations. The cellular processes occurring in cancer development mark the chromatin. These epigenetic marks are reflected by modifications in the cfDNA methylation, fragment size, and structure. In this review, we describe how going beyond DNA sequence information alone, by analyzing cfDNA epigenetic and immune signatures, boosts the potential of liquid biopsy for the early detection of cancer.

引用

页码：350 / 368

页数：19

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