Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats

被引：32

作者：

Jiang, Yao ^{[1
,2
]}

Fu, Chuhan ^{[1
,2
]}

Liu, Guihua ^{[3
]}

Guo, Jiao ^{[2
]}

Su, Zhengquan ^{[1
,2
]}

机构：

[1] Guangdong Pharmaceut Univ, Guangdong Engn Res Ctr Nat Prod & New Drugs, Guangzhou, Guangdong, Peoples R China

[2] Guangdong Pharmaceut Univ, Key Unit Modulating Liver Treat Hyperlipemia SATC, Guangdong Metab Dis Res Ctr Integrated Chinese &, Guangzhou, Guangdong, Peoples R China

[3] Shenzhen Ctr Dis Control & Prevent, Shenzhen, Peoples R China

来源：

FOOD & NUTRITION RESEARCH | 2018年 / 62卷

基金：

美国国家科学基金会;

关键词：

chitosan oligosaccharide; antihyperlipidemic; gene difference expression; high-fat diet; CYP7; A1; HMGCR; FATTY LIVER-DISEASE; CHITOSAN OLIGOSACCHARIDE; BIOLOGICAL-ACTIVITIES; LIPID-ACCUMULATION; X RECEPTOR; DIET; MICE; EXPRESSION; DERIVATIVES; EXTRACTS;

D O I：

10.29219/fnr.v62.1446

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Background: Chitooligosaccharide (COS) has shown potential antihyperlipidemic activity in a few studies as a functional Food. Method: We investigated the cholesterol-lowering effect and potential mechanisms of chitooligosaccharide capsules (COSTC) in male SD rats fed a high-fat diet. Results: COSTC could ameliorate serum lipid levels. Simultaneously, the cholesterol-lowering effect is probably attributed to its role in two pathways: upregulating the gene expression and activity of cholesterol 7 alpha-hydroxylase (CYP7A1), liver X receptor alpha (LXRA), and peroxisome proliferation activated receptor-a (PPARa), which facilitates the conversion of cholesterol into bile acid; downregulating the gene expression and activity of enzymes including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and sterol-responsive element binding protein-2 (SREBP2) and upregulating the low-density lipoprotein receptor (I,DLR) to reduce the denovo synthesis of cholesterol. Conclusion: Studies have suggested that COSTC has potential usefulness as a natural supplement or functional food for preventing and treating hyperlipidemia.

引用

页数：15

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