The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection

被引：16
作者：
Kalhori, Mohammad Reza [1 ]
Saadatpour, Fatemeh [2 ]
Arefian, Ehsan [2 ]
Soleimani, Masoud [3 ]
Farzaei, Mohammad Hosien [4 ]
Aneva, Ina Yosifova [5 ]
Echeverria, Javier [6 ]
机构：
[1] Kermanshah Univ Med Sci, Hlth Technol Inst, Med Biol Res Ctr, Kermanshah, Iran
[2] Univ Tehran, Coll Sci, Sch Biol, Dept Microbiol,Mol Virol Lab, Tehran, Iran
[3] Tarbiat Modares Univ, Fac Med Sci, Dept Hematol, Tehran, Iran
[4] Kermanshah Univ Med Sci, Hlth Technol Inst, Med Technol Res Ctr, Kermanshah, Iran
[5] Bulgarian Acad Sci, Inst Biodivers & Ecosyst Res, Sofia, Bulgaria
[6] Univ Santiago Chile, Fac Quim & Biol, Dept Ciencias Ambiente, Santiago, Chile
来源：
FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷
关键词：
coronavirus; miRNA; siRNA; natural products; phytochemicals; SARS-CoV-2; RESPIRATORY-SYNDROME CORONAVIRUS; PAPAIN-LIKE PROTEASE; COV 3CL PROTEASE; SARS-CORONAVIRUS; SPIKE PROTEIN; NUCLEOCAPSID PROTEIN; VIRUS-REPLICATION; CULTURED-CELLS; DENGUE VIRUS; KAPPA-B;
D O I：
10.3389/fphar.2021.616993
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The SARS-CoV-2 virus was reported for the first time in Wuhan, Hubei Province, China, and causes respiratory infection. This pandemic pneumonia killed about 1,437,835 people out of 61,308,161cases up to November 27, 2020. The disease's main clinical complications include fever, recurrent coughing, shortness of breath, acute respiratory syndrome, and failure of vital organs that could lead to death. It has been shown that natural compounds with antioxidant, anticancer, and antiviral activities and RNA interference agents could play an essential role in preventing or treating coronavirus infection by inhibiting the expression of crucial virus genes. This study aims to introduce a summary of coronavirus's genetic and morphological structure and determine the role of miRNAs, siRNAs, chemical drugs, and natural compounds in stimulating the immune system or inhibiting the virus's structural and non-structural genes that are essential for replication and infection of SARS-CoV-2.
引用
收藏
页数：19
相关论文
共 162 条
  • [1] Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates
    Ahn, Dae-Gyun
    Choi, Jin-Kyu
    Taylor, Deborah R.
    Oh, Jong-Won
    [J]. ARCHIVES OF VIROLOGY, 2012, 157 (11) : 2095 - 2104
  • [2] Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer
    An, SW
    Chen, CJ
    Yu, X
    Leibowitz, JL
    Makino, S
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (09) : 7853 - 7859
  • [3] Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles
    Angelini, Megan M.
    Akhlaghpour, Marzieh
    Neuman, Benjamin W.
    Buchmeier, Michael J.
    [J]. MBIO, 2013, 4 (04):
  • [4] Untangling Membrane Rearrangement in the Nidovirales
    Angelini, Megan Mary
    Neuman, Benjamin William
    Buchmeier, Michael J.
    [J]. DNA AND CELL BIOLOGY, 2014, 33 (03) : 122 - 127
  • [5] Natural products' role against COVID-19
    Antonio, Ananda da Silva
    Moreira Wiedemann, Larissa Silveira
    Veiga-Junior, Valdir Florencio
    [J]. RSC ADVANCES, 2020, 10 (39) : 23379 - 23393
  • [6] Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous Bat
    Banerjee, Arinjay
    Falzarano, Darryl
    Rapin, Noreen
    Lew, Jocelyne
    Misra, Vikram
    [J]. VIRUSES-BASEL, 2019, 11 (02):
  • [7] Barreca D., 2019, ANIMAL SCI PAPERS RE, V36, P345
  • [8] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
    Bartel, David P.
    [J]. CELL, 2007, 131 (04) : 11 - 29
  • [9] Emerging Role of MicroRNAs and Long Noncoding RNAs in Respiratory Disease
    Booton, Richard
    Lindsay, Mark A.
    [J]. CHEST, 2014, 146 (01) : 193 - 204
  • [10] The coronavirus spike protein is a class I virus fusion protein: Structural and functional characterization of the fusion core complex
    Bosch, BJ
    van der Zee, R
    de Haan, CAM
    Rottier, PJM
    [J]. JOURNAL OF VIROLOGY, 2003, 77 (16) : 8801 - 8811
12345678910