Syntheses and anti-cancer activities of 2-[1-(indo1-3-yl-/pyrimidin-5-yl-/pyridine-2-yl-/quinolin-2-yl)-but-3-enylaminol-2-phenyl-ethanols

被引：33
|
作者：
Singh, Palwinder [1 ]
Kaur, Pervinder
Luxami, Vijay
Kaur, Satwinderjit
Kumar, Subodh
机构：
[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India
[2] Guru Nanak Dev Univ, Dept Bot & Environm Sci, Amritsar 143005, Punjab, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 06期
关键词：
heterocycles; Schiff bases; indium; allylation; in vitro; anti-cancer activities;
D O I：
10.1016/j.bmc.2007.01.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Schiff bases prepared by the reactions of substituted amines with indole-/, pyrimidine-/, pyridine-/, and quinoline-aldehydes are made to undergo indium mediated allylation whereby a (substituted amine, allyl)methyl group has been introduced at C-3 of indole, C-5 of pyrimidine, and C-2 of pyridine and quinoline. Amongst the 16 compounds investigated for anti-cancer activities at 59 human tumor cell lines 3, 9-12, and 14 show appreciable activities. The structure-activity relationship studies point that the contribution of phenylglycinol moiety as a part of side chain at C-3 of indole and C-5 of pyrimidine seems to be crucial for exhibiting anti-cancer activities. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2386 / 2395
页数：10
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