LC-MS analysis of basic pharmaceuticals (beta-blockers and anti-ulcer agents) in wastewater and surface water

被引：110
作者：
Hernando, Ma. Dolores [1 ]
Gomez, Ma. Jose [1 ]
Aguera, Ana [1 ]
Fernandez-Alba, Amadeo R. [1 ]
机构：
[1] Univ Almeria, Dept Hydrogeol & Analyt Chem, E-04120 Ameria, Spain
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2007年 / 26卷 / 06期
关键词：
anti-ulcer agent; beta-blocker; liquid chromatography; mass spectrometry; surface water; wastewater;
D O I：
10.1016/j.trac.2007.03.005
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Given the concern for assessing environmental exposure due to the presence of pharmaceuticals and their potential impact, most studies carried out in this field have been on the development of analytical methods. Beta-blockers and anti-ulcer agents are pharmaceuticals with amine functionalities and basic sites in the molecules that can cause difficulties in their analysis. This review compiles the advances presented in the current literature as approaches to solving the difficulties in the analysis of basic pharmaceuticals by using liquid chromatography with mass spectrometry systems and sample treatment for complex matrices. We also compile environmental findings for beta-blockers and anti-ulcer agents in this review. (C) 2007 Elsevier Ltd. All rights reserved.
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页码：581 / 594
页数：14
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