Association of the Age at Menarche with Site-Specific Cancer Risks in Pooled Data from Nine Cohorts

被引：46

作者：

Fuhrman, Barbara J. ^{[1
,2
]}

Moore, Steven C. ^{[3
]}

Byrne, Celia ^{[4
]}

Makhoul, Issam ^{[2
]}

Kitahara, Cari M. ^{[3
]}

de Gonzalez, Amy Berrington ^{[3
]}

Linet, Martha S. ^{[3
]}

Weiderpass, Elisabete ^{[5
]}

Adami, Hans-Olov ^{[6
,7
]}

Freedman, Neal D. ^{[3
]}

Liao, Linda M. ^{[3
]}

Matthews, Charles E. ^{[3
]}

Stolzenberg-Solomon, Rachael Z. ^{[3
]}

Gaudet, Mia M. ^{[3
,8
]}

Patel, Alpa V. ^{[8
]}

Lee, I-Min ^{[9
]}

Buring, Julie E. ^{[9
]}

Wolk, Alicja ^{[10
]}

Larsson, Susanna C. ^{[10
]}

Prizment, Anna E. ^{[11
]}

Robien, Kim ^{[12
]}

Spriggs, Michael ^{[13
]}

Check, David P. ^{[3
]}

Murphy, Neil ^{[14
]}

Gunter, Marc J. ^{[14
]}

Van Dusen, Harold L., Jr. ^{[13
]}

Ziegler, Regina G. ^{[3
]}

Hoover, Robert N. ^{[3
]}

机构：

[1] Univ Pittsburgh, Pittsburgh, PA USA

[2] Univ Arkansas Med Sci, Little Rock, AR 72205 USA

[3] NIH, Div Canc Epidemiol & Genet, Rockville, MD USA

[4] Uniformed Hlth Serv Univ, Bethesda, MD USA

[5] World Hlth Org, Int Agcy Res Canc, Lyon, France

[6] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA

[7] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[8] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[9] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[10] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[11] Univ Minnesota, Masonic Canc Ctr, Div Hematol Oncol & Transplantat, Minneapolis, MN USA

[12] George Washington Univ, Exercise & Nutr Sci, Publ Hlth, Washington, DC USA

[13] Informat Management Serv Inc, Rockville, MD USA

[14] World Hlth Org, Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France

来源：

CANCER RESEARCH | 2021年 / 81卷 / 08期

基金：

瑞典研究理事会;

关键词：

NIH-AARP DIET; DOSE-RESPONSE METAANALYSIS; MENOPAUSAL HORMONE-THERAPY; REPRODUCTIVE FACTORS; ENDOMETRIAL CANCER; PHYSICAL-ACTIVITY; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; BREAST-CANCER; HEALTH;

D O I：

10.1158/0008-5472.CAN-19-3093

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The average age at menarche declined in European and U.S. populations during the 19th and 20th centuries. The timing of pubertal events may have broad implications for chronic disease risks in aging women. Here we tested for associations of recalled menarcheal age with risks of 19 cancers in 536,450 women [median age, 60 years (range, 31-39 years)] in nine prospective U.S. and European cohorts that enrolled participants from 1981 to 1998. Cox regression estimated multivariable-adjusted HRs and 95% confidence intervals (CI) for associations of the age at menarche with risk of each cancer in each cohort and random-effects meta-analysis was used to generate summary estimates for each cancer. Over a median 10 years of follow-up, 60,968 women were diagnosed with a first primary incident cancer. Inverse linear associations were observed for seven of 19 cancers studied. Each additional year in the age at menarche was associated with reduced risks of endometrial cancer (HR = 0.91; 95% CI, 0.89-0.94), liver cancer (HR = 0.92; 95% CI, 0.85-0.99), melanoma (HR = 0.95; 95% CI, 0.93-0.98), bladder cancer (HR = 0.96; 95% CI, 0.93-0.99), and cancers of the colon (HR = 0.97; 95% CI, 0.96-0.99), lung (HR = 0.98; 95% CI, 0.96-0.99), and breast (HR = 0.98; 95% CI, 0.93-0.99). All but one of these associations remained statistically significant following adjustment for baseline body mass index. Similarities in the observed associations between menarche and seven cancers suggest shared underlying causes rooted early in life. We propose as a testable hypothesis that early exposure to sex hormones increases mid-life cancer risks by altering functional capacities of stem cells with roles in systemic energy balance and tissue homeostasis. Significance: Age at menarche is associated with risk for seven cancers in middle-aged women, and understanding the shared underlying causal pathways across these cancers may suggest new avenues for cancer prevention.

引用

页码：2246 / 2255

页数：10

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