New diterpenoids from Caesalpinia species and their cytotoxic activity

被引：26

作者：

Das, Biswanath ^{[1
]}

Srinivas, Yallamalla ^{[1
]}

Sudhakar, Chithaluri ^{[1
]}

Mahender, Ibram ^{[1
]}

Laxminarayana, Keetha ^{[1
]}

Reddy, Parigi Raghavendar ^{[1
]}

Raju, Tuniki Venugopal ^{[2
]}

Jakka, Naga Mahesh ^{[3
]}

Rao, Janapala Venkateswara ^{[3
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, NMR Div, Hyderabad 500007, Andhra Pradesh, India

[3] Indian Inst Chem Technol, Div Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 09期

关键词：

Caesalpinia crista; C; pulcherrima; Leguminaceae; Diterpenoid; Structure elucidation; Cytotoxic activity; PULCHERRIMA; HOMOISOFLAVONOIDS;

D O I：

10.1016/j.bmcl.2010.03.048

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigation on Caesalpinia crista afforded two new diterpenoids, 6 beta-cinnamoyloxy-7 beta-acetoxyvouacapen-5 alpha-ol and 6 beta,7 beta-dibenzoyloxyvouacapen-5 alpha-ol and on Caesalpinia pulcherrima another new diterpenoid, 12-demethyl neocaesalpin F along with several known constituents. The structures of the new compounds were settled from their 1D and 2D NMR spectral data. The cytotoxicity of these compounds was measured on two different cancer cell lines. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2847 / 2850

页数：4

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