Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

被引：38

作者：

Xie, Yong-Sheng ^{[1
]}

Zhao, Hong-Ling ^{[2
]}

Su, Hua ^{[2
]}

Zhao, Bao-Xiang ^{[1
]}

Liu, Jin-Ting ^{[1
]}

Li, Ji-Kun ^{[3
]}

Lv, Hong-Shui ^{[1
]}

Wang, Bai-Shan ^{[1
]}

Shin, Dong-Soo ^{[4
]}

Miao, Jun-Ying ^{[2
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Shandong Univ, Sch Life Sci, Jinan 250100, Peoples R China

[3] Taishan Univ, Dept Mat Sci & Chem Engn, Tai An 271021, Shandong, Peoples R China

[4] Changwon Natl Univ, Dept Chem, Chang Won 641773, South Korea

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Ferrocene; Pyrazole-fused pyrazinone; Synthesis; X-ray structure; A549 lung cancer cell; GLYCOPROTEIN IIB/IIIA INHIBITORS; ORALLY BIOAVAILABLE INHIBITOR; POTENTIAL AGENTS; PYRAZIN-4(5H)-ONE DERIVATIVES; HYDRAZONE DERIVATIVES; HIGHLY POTENT; DESIGN; CELL; DISCOVERY; SERIES;

D O I：

10.1016/j.ejmech.2009.09.046

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H))-one derivatives was synthesized and characterized by H-1 NMR, C-13 NMR, IR, HRMS and X-ray diffraction analysis. Preliminary evaluation of biological applications showed that the compounds 6c and 6f inhibit the growth of A549 cells in dosage-dependent manners through cell cycle arrest. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：210 / 218

页数：9

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