Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval

被引：21

作者：

Lux, Vanessa ^{[1
]}

Atucha, Erika ^{[1
,2
,3
]}

Kitsukawa, Takashi ^{[4
]}

Sauvage, Magdalena M. ^{[1
,2
,3
]}

机构：

[1] Ruhr Univ Bochum, Fac Med, Mercator Res Grp, Funct Architecture Memory Unit, Univ Str 150, Bochum, Germany

[2] Otto Von Guericke Univ, Funct Neuroplast Dept, Magdeburg, Germany

[3] Leibniz Inst Neurobiol, Funct Architecture Memory Dept, Magdeburg, Germany

[4] Osaka Univ, Grad Sch Frontier Biosci, Osaka, Japan

来源：

ELIFE | 2016年 / 5卷

关键词：

EARLY GENE ARC; RETROGRADE-AMNESIA; RECOGNITION MEMORY; CONTEXTUAL FEAR; AUTOBIOGRAPHICAL MEMORY; BASOLATERAL AMYGDALA; HIPPOCAMPAL COMPLEX; PERIRHINAL CORTEX; REMOTE MEMORIES; NMDA RECEPTORS;

D O I：

10.7554/eLife.11862

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Whether retrieval still depends on the hippocampus as memories age or relies then on cortical areas remains a major controversy. Despite evidence for a functional segregation between CA1, CA3 and parahippocampal areas, their specific role within this frame is unclear. Especially, the contribution of CA3 is questionable as very remote memories might be too degraded to be used for pattern completion. To identify the specific role of these areas, we imaged brain activity in mice during retrieval of recent, early remote and very remote fear memories by detecting the immediate-early gene Arc. Investigating correlates of the memory trace over an extended period allowed us to report that, in contrast to CA1, CA3 is no longer recruited in very remote retrieval. Conversely, we showed that parahippocampal areas are then maximally engaged. These results suggest a shift from a greater contribution of the trisynaptic loop to the temporoammonic pathway for retrieval.

引用

页数：19

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