Between a rock and a hard place: Regulation of mineralization in the periodontium

被引：10
作者：
Andras, Natalie L. [1 ]
Mohamed, Fatma F. [1 ]
Chu, Emily Y. [2 ]
Foster, Brian L. [1 ]
机构：
[1] Ohio State Univ, Coll Dent, Biosci Div, 4163 Postle Hall,305 W 12th Ave, Columbus, OH 43210 USA
[2] Univ Maryland, Sch Dent, Dept Gen Dent, Div Operat Dent, Baltimore, MD 21201 USA
来源：
GENESIS | 2022年 / 60卷 / 8-9期
关键词：
alveolar bone; cementum; extracellular matrix; mineralization; periodontal; NONSPECIFIC ALKALINE-PHOSPHATASE; VITAMIN-D-RECEPTOR; MOUSE MODEL; DENTIN SIALOPHOSPHOPROTEIN; BONE SIALOPROTEIN; EXTRACELLULAR-MATRIX; REPLACEMENT THERAPY; ACELLULAR CEMENTUM; ROOT DEVELOPMENT; TOOTH;
D O I：
10.1002/dvg.23474
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The periodontium supports and attaches teeth via mineralized and nonmineralized tissues. It consists of two, unique mineralized tissues, cementum and alveolar bone. In between these tissues, lies an unmineralized, fibrous periodontal ligament (PDL), which distributes occlusal forces, nourishes and invests teeth, and harbors progenitor cells for dentoalveolar repair. Many unanswered questions remain regarding periodontal biology. This review will focus on recent research providing insights into one enduring mystery: the precise regulation of the hard-soft tissue borders in the periodontium which define the interfaces of the cementum-PDL-alveolar bone structure. We will focus on advances in understanding the molecular mechanisms that maintain the unmineralized PDL "between a rock and a hard place" by regulating the mineralization of cementum and alveolar bone.
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页数：22
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