Cystatins in cancer progression: More than just cathepsin inhibitors

被引：61
作者：
Breznik, Barbara [1 ]
Mitrovic, Ana [2 ]
Lah, Tamara T. [1 ,3 ]
Kos, Janko [2 ,4 ]
机构：
[1] Natl Inst Biol, Dept Genet Toxicol & Canc Biol, Vecna Pot 111, Ljubljana 1000, Slovenia
[2] Jozef Stefan Inst, Dept Biotechnol, Jamova 39, Ljubljana 1000, Slovenia
[3] Univ Ljubljana, Fac Chem & Chem Engn, Vecna Pot 113, Ljubljana 1000, Slovenia
[4] Univ Ljubljana, Fac Pharm, Askerceva Cesta 7, Ljubljana 1000, Slovenia
来源：
BIOCHIMIE | 2019年 / 166卷
关键词：
Biomarker; Cathepsin; Cystatin; Invasion; Metastasis; Antitumor immune response; SQUAMOUS-CELL CARCINOMA; CYSTEINE PROTEINASE-INHIBITORS; TUMOR-SUPPRESSOR GENE; EPITHELIAL-MESENCHYMAL TRANSITION; INDEPENDENT PROGNOSTIC-FACTOR; BRONCHOALVEOLAR LAVAGE FLUID; HUMAN COLORECTAL-CANCER; RAY CRYSTAL-STRUCTURE; NATURAL-KILLER-CELLS; GROWTH-FACTOR-BETA;
D O I：
10.1016/j.biochi.2019.05.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cystatins are endogenous and reversible inhibitors of cysteine peptidases that are important players in cancer progression. Besides their primary role as regulators of cysteine peptidase activity, cystatins are involved in cancer development and progression through proteolysis-independent mechanisms. Mechanistic studies of cystatin function revealed that they affect all stages of cancer progression including tumor growth, apoptosis, invasion, metastasis and angiogenesis. Recently, the involvement of cystatins in the antitumor immune responses was reported. In this review, we discuss molecular mechanisms and clinical aspects of cystatins in cancer. Altered expression of cystatins in cancer resulting in harmful excessive cysteine peptidase activity has been a subject of several studies in order to find correlations with clinical outcome and therapy response. However, involvement in anti-tumor immune response and signaling cascades leading to cancer progression designates cystatins as possible targets for development of new anti-tumor drugs. (C) 2019 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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收藏
页码：233 / 250
页数：18
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