Detection of chromosome 15 deletion in Prader-Willi syndrome using fluorescence in situ hybridization

被引：0

作者：

Suzuki, Y ^{[1
]}

Sasagawa, I ^{[1
]}

Yazawa, H ^{[1
]}

Tateno, T ^{[1
]}

Nakada, T ^{[1
]}

机构：

[1] Yamagata Univ, Sch Med, Dept Urol, Yamagata 9909585, Japan

来源：

ARCHIVES OF ANDROLOGY | 2000年 / 45卷 / 01期

关键词：

chromosome analysis; fluorescence in situ hybridization; Prader-Willi syndrome;

D O I：

暂无

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Deletion of chromosome 15 was investigated in 6 patients with Prader-Willi syndrome (PWS) using chromsome and fluorescence in situ hybridization (FISH) analysis. Although chromosome analysis using G-banding methods revealed the deletion of 15q11-q13 in only 3 cases, staining by FISH using D15S11 and/or small nuclear ribonucleoprotein polypeptide N (SNRPN) probes detected chromosome 15 deletion in all cases. It would appear that FISH analysis is an effective diagnostic test for the detection of chromosome 15 deletion in patients with PWS.

引用

页码：13 / 17

页数：5