Association of plasma folate, vitamin B12 levels, and arsenic methylation capacity with developmental delay in preschool children in Taiwan

被引：17

作者：

Lin, Ying-Chin ^{[1
,2
,3
,4
]}

Chung, Chi-Jung ^{[5
,6
]}

Huang, Ya-Li ^{[7
]}

Hsieh, Ru-Lan ^{[8
,9
]}

Huang, Pai-Tsang ^{[10
]}

Wu, Mei-Yi ^{[11
,12
]}

Ao, Pui-Lam ^{[13
]}

Shiue, Horng-Sheng ^{[14
]}

Huang, Shiau-Rung ^{[13
]}

Su, Chien-Tien ^{[13
,15
]}

Lin, Ming-I ^{[16
]}

Mu, Shu-Chi ^{[16
]}

Hsueh, Yu-Mei ^{[1
,7
]}

机构：

[1] Taipei Med Univ, Shuang Ho Hosp, Dept Family Med, New Taipei, Taiwan

[2] Taipei Med Univ, Wan Fang Hosp, Dept Hlth Examinat, Taipei, Taiwan

[3] Taipei Med Univ, Coll Med, Sch Med, Dept Family Med, Taipei, Taiwan

[4] Taipei Med Univ, Coll Med, Sch Med, Dept Geriatr Med, Taipei, Taiwan

[5] China Med Univ, Coll Publ Hlth, Dept Publ Hlth, Taichung, Taiwan

[6] China Med Univ & Hosp, Dept Med Res, Taichung, Taiwan

[7] Taipei Med Univ, Coll Med, Sch Med, Dept Publ Hlth, Taipei, Taiwan

[8] Shin Kong Wu Ho Mem Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan

[9] Taipei Med Univ, Coll Med, Sch Med, Dept Phys Med & Rehabil, Taipei, Taiwan

[10] Taipei Med Univ, Wan Fang Hosp, Dept Occupat Med, Taipei, Taiwan

[11] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med,Div Nephrol, Taipei, Taiwan

[12] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Nephrol, New Taipei, Taiwan

[13] Taipei Med Univ, Coll Publ Hlth, Sch Publ Hlth, Taipei, Taiwan

[14] Chang Gung Univ, Coll Med, Dept Chinese Med, Taoyuan, Taiwan

[15] Taipei Med Univ Hosp, Dept Family Med, Taipei, Taiwan

[16] Shin Kong Wu Ho Mem Hosp, Dept Pediat, Taipei, Taiwan

来源：

ARCHIVES OF TOXICOLOGY | 2019年 / 93卷 / 09期

关键词：

Folate; Vitamin B12; Arsenic; Arsenic methylation; Developmental delay; COGNITIVE FUNCTION; EXPOSURE; METABOLISM; POLYMORPHISM; DISORDERS; PREGNANCY; BRAIN; CELLS;

D O I：

10.1007/s00204-019-02540-4

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Developmental delay has been associated with inefficient arsenic methylation capacity in preschool children. Folate and vitamin B12 are important nutrients that produce s-adenosylmethionine during single-carbon metabolism and provide methyl groups for arsenic methylation. The aim of the present study was to explore whether plasma folate and vitamin B12 levels influence arsenic methylation capacity and in turn are related to developmental delay in preschool children. A case-control study was conducted in 178 children with developmental delay and 88 normal children, who were recruited from Shin Kong Wu Ho-Su Memorial Teaching Hospital from August 2010 to March 2014. Arsenite (As-III), arsenate (As-V), monomethylarsonic acid (MMA(V)), and dimethylarsinic acid (DMA(V)) in the urine was determined by high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Plasma folate and vitamin B12 levels were measured using a SimulTRAC-SNB radioassay. The results show that the combination of high plasma folate and high vitamin B12 levels were correlated with efficient arsenic methylation capacity (low MMA(V) %, low InAs %, and high DMA(V) %). High MMA(V) % significantly increased and high DMA(V) % and secondary methylation index decreased the odds ratio (OR) of developmental delay in a dose-dependent manner in both low plasma folate and low vitamin B12 (low/low) groups; the multivariate OR and 95% confidence interval were 5.01 (0.83-30.06), 0.21 (0.04-1.23), and 0.20 (0.03-1.20), respectively. This is the first study to show that the combination of high plasma folate and high vitamin B12 levels increases arsenic methylation capacity and indirectly decreases the OR of developmental delay in preschool children.

引用

页码：2535 / 2544

页数：10

共 36 条

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