A model for temporal heterogeneities of tumor blood flow

被引：51

作者：

Mollica, F

Jain, RK

Netti, PA

机构：

[1] Univ Naples Federico II, Dept Mat & Prod Engn, I-80125 Naples, Italy

[2] CNR, Inst Composite Mat Technol, Naples, Italy

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Radiat Oncol, Boston, MA 02114 USA

来源：

MICROVASCULAR RESEARCH | 2003年 / 65卷 / 01期

关键词：

tumor blood flow; temporal heterogeneities; mathematical modeling; tumor vascular permeability;

D O I：

10.1016/S0026-2862(02)00012-2

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Tumor blood flow (TBF) plays a fundamental role in tumor growth and treatment, and is characterized by spatial and temporal heterogeneities. Here we show that the interstitial fluid pressure (IFP), which is higher in tumoral tissue than in normal tissue, coupled with the tumor microvascular pressure (MVP) and the higher permeability of tumoral vessels, can explain the sustained oscillatory behavior of TBF, observed in vivo. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：56 / 60

页数：5

共 14 条

[1]

[Anonymous], 1960, HYDRODYNAMICS STUDY

[2] Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors [J].