Scaffold Distributions in Bioactive Molecules, Clinical Trials Compounds, and Drugs

被引：19

作者：

Hu, Ye ^{[1
]}

Bajorath, Juergen ^{[1
]}

机构：

[1] Univ Bonn, Dept Life Sci Informat, B IT, LIMES Program Unit Chem Biol & Med Chem, D-53113 Bonn, Germany

来源：

CHEMMEDCHEM | 2010年 / 5卷 / 02期

关键词：

bioactive molecules; clinical trials compounds; drugs; molecular scaffolds; scaffold distributions; statistical analysis; MEDICINAL CHEMISTRY; DATABASES; FRAGMENTS; SUBSTRUCTURES; DISCOVERY; SPACE;

D O I：

10.1002/cmdc.200900419

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Figure Presented) Analysis of pharmaceutically relevant molecular frameworks: Structural features of compounds at different stages of pharmaceutical development were analyzed and compared. Shown here is a Venn diagram that compares scaffold sets extracted from bioactive molecules, clinical trials compounds, and drugs. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：187 / 190

页数：4

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