Acute Disseminated Encephalomyelitis Following Chemoradiotherapy in an Adult Patient With Nasopharyngeal Cancer

被引：2

作者：

Esakia, Tamar ^{[1
]}

Antia, Tamar ^{[2
]}

Janelidze, Marina ^{[3
]}

Mariamidze, Armaz ^{[4
]}

Okujava, Mikheil ^{[2
]}

机构：

[1] Acad F Todua Med Ctr, Oncol & Hematol, Tbilisi, Georgia

[2] Acad F Todua Med Ctr, Radiol, Tbilisi, Georgia

[3] S Khechinashvili Univ Hosp, Neurol, Tbilisi, Georgia

[4] Acad F Todua Med Ctr, Pathol, Tbilisi, Georgia

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 03期

关键词：

chemoradiation-induced neurotoxicity; nasopharyngeal cancer; brain metastases; acute disseminated encephalomyelitis; adem; chemoradiation-induced demyelination; CENTRAL-NERVOUS-SYSTEM; METASTASIS; CARCINOMA;

D O I：

10.7759/cureus.14137

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute disseminated encephalomyelitis (ADEM) is a monophasic demyelinating disorder predominantly affecting children. It typically follows a viral illness or vaccination. We present a case of a 34-year-old white male treated with chemo-radiotherapy for nasopharyngeal cancer who developed ADEM. Prompt initiation of intravenous steroids led to the resolution of symptoms and normalization of the brain imaging. We hypothesized that direct brain tissue damage by chemotherapy and radiation therapy, combined possibly with a viral infection, triggered an immune inflammatory response and subsequent demyelination.

引用

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