Sphincter of Oddi Function and Risk Factors for Dysfunction

被引：51

作者：

Afghani, Elham ^{[1
]}

Lo, Simon K. ^{[1
]}

Covington, Paul S. ^{[2
]}

Cash, Brooks D. ^{[3
]}

Pandol, Stephen J. ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[2] Clin Dynamix, Wilmington, NC USA

[3] Univ S Alabama, Mobile, AL USA

来源：

FRONTIERS IN NUTRITION | 2017年 / 4卷

关键词：

pancreatitis; sphincter of Oddi; sphincter of Oddi dysfunction; functional biliary disorder; biliary colic; hepatic enzymes; lipase; amylase; COMMON BILE-DUCT; INDUCED ACUTE-PANCREATITIS; DRUG-INDUCED PANCREATITIS; IRRITABLE-BOWEL-SYNDROME; SUSPECTED SPHINCTER; BILIARY DYSKINESIA; ANALGESIC DRUGS; LAPAROSCOPIC CHOLECYSTECTOMY; POSTCHOLECYSTECTOMY SYNDROME; CHOLEDOCHODUODENAL JUNCTION;

D O I：

10.3389/fnut.2017.00001

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The sphincter of Oddi (SO) is a smooth muscle valve regulating the flow of biliary and pancreatic secretions into the duodenum, initially described in 1887 by the Italian anatomist, Ruggero Oddi. SO dysfunction (SOD) is a broad term referring to numerous biliary, pancreatic, and hepatic disorders resulting from spasms, strictures, and relaxation of this valve at inappropriate times. This review brings attention to various factors that may increase the risk of SOD, including but not limited to: cholecystectomy, opiates, and alcohol. Lack of proper recognition and treatment of SOD may be associated with clinical events, including pancreatitis and biliary symptoms with hepatic enzyme elevation. Pharmacologic and non-pharmacologic approaches are discussed to help recognize, prevent, and treat SOD. Future studies are needed to assess the treatment benefit of agents such as calcium-channel blockers, glyceryl trinitrate, or tricyclic antidepressants in patients with SOD.

引用

页数：9

共 111 条

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