Markers of Endothelial Dysfunction: E-selectin, Endothelin-1 and von Willebrand Factor in Patients with Coronary Heart Disease, Including in Combination with Type 2 Diabetes Mellitus

被引：2
|
作者：
Zhito, Alexey, V [1 ]
Iusupova, Alfia O. [1 ]
Privalova, Elena, V [1 ]
Khabarova, Natalia, V [1 ]
Belenkov, Yurii N. [1 ]
机构：
[1] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Trubetskaya Ul 8-2, Moscow 119991, Russia
来源：
RATIONAL PHARMACOTHERAPY IN CARDIOLOGY | 2019年 / 15卷 / 06期
关键词：
ischemic heart disease; diabetes mellitus type 2; E-selectin; von Willebrand factor; endothelin-1; endothelial dysfunction; SOLUBLE E-SELECTIN; CIRCULATING ADHESION MOLECULES; ARTERY-DISEASE; INFLAMMATORY MARKERS; P-SELECTIN; GLUCOSE; ASSOCIATION; RISK; BIOMARKERS; DIAGNOSIS;
D O I：
10.20996/1819-6446-2019-15-6-892-899
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The prevalence of coronary heart disease (CHD) and type 2 diabetes mellitus (type 2 diabetes) in Russia and in the world continues to increase. Despite the prevention and optimization of therapy, CHD retains its leadership among all causes of death, and the mortality rate from type 2 diabetes and its complications gradually increases too. To improve the treatment of the above mentioned diseases, it is necessary to clarify the pathogenetic mechanisms of their development. The formation of endothelial dysfunction, characterized by an increase in the level of cell adhesion molecules and vasoconstriction, is a common link characteristic for the course and progression of CHD and type 2 diabetes. This article presents an analysis of pre-and clinical studies on the role of endothelial dysfunction markers: cell adhesion molecules (E-selectin), vasoconstriction (endothelin-1) and von Willebrand factor in patients with CHD, including those with type 2 diabetes mellitus.
引用
收藏
页码：892 / 899
页数：8
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