Relationship Between the Structure of Methoxylated and Hydroxylated Flavones and Their Antiproliferative Activity in HL60 Cells

被引：19
作者：
Kawaii, Satoru [1 ]
Ishikawa, Yuya [1 ]
Yoshizawa, Yuko [2 ]
机构：
[1] Tokyo Denki Univ, Lab Bioorgan Chem, Saitama, Japan
[2] Akita Prefectural Univ, Lab Bioorgan Chem, Akita, Japan
来源：
ANTICANCER RESEARCH | 2018年 / 38卷 / 10期
关键词：
Methoxyflavone; hydroxyflavone; antiproliferative activity; HL60; cells; structure and activity relationship; MOUSE MACROPHAGES; NOBILETIN; CANCER; POLYMETHOXYFLAVONES; ANTICANCER; LINES;
D O I：
10.21873/anticanres.12904
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
As part of our continuing investigation on flavonoid derivatives as potential anticancer substances, a series of methoxylated and hydroxylated flavones was synthesized, and their cytotoxic and anti-proliferative activity was evaluated in leukemic HL60 cells. Their structureactivity relationship was also investigated. The correlation between the methoxylation/hydroxylation pattern and antiproliferative activity revealed the importance of the 5,4'and 3' ,4'-dihydroxyl moieties in flavone nucleus.
引用
收藏
页码：5679 / 5684
页数：6
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