Facile preparation of 3-amino-4-(arylamino)-1H-isochromen-1-ones by a new multicomponent reaction

被引：24

作者：

Opatz, T ^{[1
]}

Ferenc, D ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55138 Mainz, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 05期

关键词：

multicomponent reactions; heterocycles; cyclization; amines; strecker reaction;

D O I：

10.1002/ejoc.200400685

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions between 2-formylbenzoic acid, various anilines and HCN result in the formation of 3-amino-4-(arylamino)-1H-isochromen-1-ones in high yield. The mechanism of this three-component condensation involves the intermediate formation of an alpha-aminonitrile and subsequent cyclizationthrough nucleophilic attack of the ortho-carboxylate at the nitrile carbon. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).

引用

页码：817 / 821

页数：5

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