Localization and mobility of glucose-coated gold nanoparticles within the brain

被引：28

作者：

Gromnicova, Radka ^{[1
]}

Yilmaz, Canan Ugur ^{[2
]}

Orhan, Nurcan ^{[3
]}

Kaya, Mehmet ^{[4
]}

Davies, Heather ^{[1
]}

Williams, Phil ^{[5
]}

Romero, Ignacio A. ^{[1
]}

Sharrack, Basil ^{[6
]}

Male, David ^{[1
]}

机构：

[1] Open Univ, Dep Life Hlth & Chem Sci, Milton Keynes MK7 6AA, Bucks, England

[2] Istanbul Univ, Inst Expt Med, Dept Lab Anim Sci, Istanbul, Turkey

[3] Istanbul Univ, Inst Expt Med, Dept Neurosci, Istanbul, Turkey

[4] Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey

[5] Midatech Pharma Plc, Abingdon, Oxon, England

[6] Univ Sheffield, Dept Neurol, Sheffield, S Yorkshire, England

来源：

NANOMEDICINE | 2016年 / 11卷 / 06期

关键词：

blood-brain barrier; brain; brain endothelium; cortex; drug delivery; glia; glyconanoparticles; gold nanoparticles; neurons; transmission electron microscopy; TRANSFERRIN RECEPTOR; LIPID-BILAYERS; DELIVERY; TRANSPORT; BARRIER; GLYCONANOPARTICLES; FUSION;

D O I：

10.2217/nnm.15.215

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To identify the localization of glucose-coated gold nanoparticles within cells of the brain after intravascular infusion which may point to the mechanism by which they cross the blood-brain barrier. Materials & methods: Tissue distribution of the nanoparticles was measured by inductively-coupled-mass spectrometry and localization within the brain by histochemistry and electron microscopy. Results & conclusion: Nanoparticles were identified within neurons and glial cells more than 10 mu m from the nearest microvessel within 10 min of intracarotid infusion. Their distribution indicated movement across the endothelial cytosol, and direct transfer between cells of the brain. The rapid movement of this class of nanoparticle (<5 nm) into the brain demonstrates their potential to carry therapeutic biomolecules or imaging reagents.

引用

页码：617 / 625

页数：9

共 28 条

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