Effectiveness of a new cosmetic treatment for melasma

被引:21
作者
Berardesca, Enzo [1 ]
Rigoni, Corinna [2 ]
Cantu, Alessandra [2 ]
Cameli, Norma [2 ]
Tedeschi, Aurora [2 ]
Laureti, Tiziana [3 ]
Agolzer, Antonina
Alfaioli, Barbara
Belloli, Cristiana
Cantelli, Maria Teresa
Capezzera, Rossana
Ciuffreda, Adriana
Corazzol, Annachiara
Curia, Sandra
Dall'Oglio, Federica
De Padova, Maria Pia
Fabbrocini, Gabriella
Farina, Sandra
Lorenzi, Sandra
Mariano, Maria
Mazzola, Giuseppina
Negosanti, Francesca
Pratico, Marisa
Russo, Nadia
机构
[1] San Gallicano Dermatol Inst, Via Chianesi 53, Rome, Italy
[2] Donne Dermatologhe Italia, Milan, Italy
[3] Univ Tuscia, Dept Econ Engn Soc & Business Org, Viterbo, Italy
关键词
depigmentation; hyperpigmentation; kojic acid; melasma; treatment;
D O I
10.1111/jocd.13203
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Melasma treatment is difficult due to extended treatment periods, suboptimal adherence, inconsistent results, and frequent relapses. Kojic acid has been shown to be effective in reducing melasma severity and is now increasingly used in cosmetic treatments. Aims The purpose of the present study was to evaluate the effectiveness of a new cosmetic treatment for melasma at 45 and 90 days. Methods Multicenter prospective study across 20 dermatology clinics/ambulatories. One hundred patients with mild-to-moderate melasma were evaluated. The primary endpoints were changes in mean modified melasma area and severity index (mMASI) score and patient-reported satisfaction at 45 and 90 days. Results The mean age of patients was 45.19 +/- 11.5 years. Most patients were female and Caucasian. Patients presented mixed (65%), epidermal (26%), and dermal (4%) types of melasma. Triggering factors were hormonal contraception (33%), pregnancy (31%), and pharmacological treatment (11%); mean disease duration was 6.7 +/- 6.8 years. Overall, a statistically significant decrease in mean mMASI scores was seen at 45 (2.19 +/- 0.182 vs 3.29 +/- 0.267, P < .0001) and 90 days (1.27 +/- 0.128 vs 3.29 +/- 0.267, P < .00001). The highest reduction in mMASI scores was observed in patients with dermal melasma. IGA scores showed a statistically significant improvement in pigmentation at 90 days (P < .00001). Conclusion The novel cosmetic treatment was associated with the improvement of melasma, as assessed by mMASI.
引用
收藏
页码:1684 / 1690
页数:7
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