Machine-Learning-Assisted Approach for Discovering Novel Inhibitors Targeting Bromodomain-Containing Protein 4
被引:40
作者:
Xing, Jing
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h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Peking Univ, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China
Univ Chinese Acad Sci, Dept Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Xing, Jing
[1
,2
,3
]
Lu, Wenchao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Univ Chinese Acad Sci, Dept Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Lu, Wenchao
[1
,3
]
Liu, Rongfeng
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai ChemPartner Co LTD, 5 Bldg,998 Halei Rd, Shanghai 201203, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Liu, Rongfeng
[4
]
Wang, Yulan
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Univ Chinese Acad Sci, Dept Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Wang, Yulan
[1
,3
]
Xie, Yiqian
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Univ Chinese Acad Sci, Dept Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Xie, Yiqian
[1
,3
]
Zhang, Hao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Univ Chinese Acad Sci, Dept Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Zhang, Hao
[1
,3
]
Shi, Zhe
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai ChemPartner Co LTD, 5 Bldg,998 Halei Rd, Shanghai 201203, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Shi, Zhe
[4
]
Jiang, Hao
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Univ Chinese Acad Sci, Dept Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Jiang, Hao
[1
,3
]
Liu, Yu-Chih
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai ChemPartner Co LTD, 5 Bldg,998 Halei Rd, Shanghai 201203, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Liu, Yu-Chih
[4
]
Chen, Kaixian
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Chen, Kaixian
[1
]
Jiang, Hualiang
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Jiang, Hualiang
[1
]
Luo, Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Luo, Cheng
[1
]
Zheng, Mingyue
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h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R ChinaChinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
Zheng, Mingyue
[1
]
机构:
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China
[3] Univ Chinese Acad Sci, Dept Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China
[4] Shanghai ChemPartner Co LTD, 5 Bldg,998 Halei Rd, Shanghai 201203, Peoples R China
SCORING FUNCTIONS;
BET BROMODOMAINS;
DRUG DISCOVERY;
DOCKING;
BINDING;
DESIGN;
CANCER;
POTENT;
IDENTIFICATION;
KINASE;
D O I:
10.1021/acs.jcim.7b00098
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
Bromodomain-containing protein 4 (BRD4) is implicated in the pathogenesis of a number of different cancers, inflammatory diseases and heart failure. Much effort has been dedicated toward discovering novel scaffold BRD4 inhibitors (BRD4is) with different selectivity profiles and potential antiresistance properties. Structure-based drug design (SBDD) and virtual screening (VS) are the most frequently used approaches. Here, we demonstrate a novel, structure based VS approach that uses machine-learning algorithms trained on the priori structure and activity knowledge to predict the likelihood that a compound is a BRD4i based on its binding pattern with BRD4. In addition to positive experimental data, such as X-ray structures of BRD4-ligand complexes and BRD4 inhibitory potencies, negative data such as false positives (FPs) identified from our earlier ligand screening results were incorporated into our knowledge base. We used the resulting data to train a machine-learning model named BRD4LGR to predict the BRD4i-likeness of a compound. BRD4LGR achieved a 20-30% higher AUC-ROC than that of Glide using the same test set. When conducting in vitro experiments against a library of previously untested, commercially available organic compounds, the second round of VS using BRD4LGR generated 15 new BRD4is. Moreover, inverting the machine-learning model provided easy access to structure-activity relationship (SAR) interpretation for hit-to-lead optimization.
机构:
Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South KoreaEwha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
Lee, Seul-Ki
Park, Eun-Jung
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h-index: 0
机构:
Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South KoreaEwha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
Park, Eun-Jung
Lee, Han-Sae
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South KoreaEwha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
Lee, Han-Sae
Lee, Ye Seul
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South KoreaEwha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
机构:
Xiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
Shen, Shang-Hang
Guo, Jian-Feng
论文数: 0引用数: 0
h-index: 0
机构:
Xiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
Guo, Jian-Feng
Huang, Ju
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
Huang, Ju
Zhang, Qian
论文数: 0引用数: 0
h-index: 0
机构:
East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
Zhang, Qian
Cui, Yi
论文数: 0引用数: 0
h-index: 0
机构:
East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Pan, Zhaoping
Li, Xiang
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Li, Xiang
Wang, Yujia
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Wang, Yujia
Jiang, Qinglin
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Med Coll, Sch Pharm, Chengdu 610500, Peoples R China
Chengdu Med Coll, Sichuan Prov Coll Key Lab Struct Specif Small Mol, Chengdu 610500, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Jiang, Qinglin
Jiang, Li
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Med Coll, Sch Pharm, Chengdu 610500, Peoples R China
Chengdu Med Coll, Sichuan Prov Coll Key Lab Struct Specif Small Mol, Chengdu 610500, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Jiang, Li
Zhang, Min
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Med Coll, Sch Pharm, Chengdu 610500, Peoples R China
Chengdu Med Coll, Sichuan Prov Coll Key Lab Struct Specif Small Mol, Chengdu 610500, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Zhang, Min
Zhang, Nan
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Zhang, Nan
Wu, Fengbo
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Wu, Fengbo
Liu, Bo
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Liu, Bo
He, Gu
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Yuan, Ling
Guo, Haolin
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Guo, Haolin
Li, Qinyang
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Li, Qinyang
Zhang, Han
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Zhang, Han
Xu, Mujian
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Xu, Mujian
Zhang, Weiming
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Zhang, Weiming
Zhang, Yanyang
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Zhang, Yanyang
Hua, Ming
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Hua, Ming
Lv, Lu
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Lv, Lu
Pan, Bingcai
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
机构:
Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung, TaiwanKaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Chuang, Kai-Ting
Wang, Shen-Nien
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung, Taiwan
Kaohsiung Med Univ Hosp, Coll Med, Dept Surg, Kaohsiung, Taiwan
Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung, TaiwanKaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Wang, Shen-Nien
Hsu, Shih-Hsien
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, TaiwanKaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Hsu, Shih-Hsien
Wang, Li-Ting
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Normal Univ, Dept Life Sci, Taipei, Taiwan
Kaohsiung Med Univ, Ctr Appl Genom, Kaohsiung, TaiwanKaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
机构:
Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South KoreaEwha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
Lee, Seul-Ki
Park, Eun-Jung
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South KoreaEwha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
Park, Eun-Jung
Lee, Han-Sae
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South KoreaEwha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
Lee, Han-Sae
Lee, Ye Seul
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South KoreaEwha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
机构:
Xiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
Shen, Shang-Hang
Guo, Jian-Feng
论文数: 0引用数: 0
h-index: 0
机构:
Xiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
Guo, Jian-Feng
Huang, Ju
论文数: 0引用数: 0
h-index: 0
机构:
Shanghai Normal Univ, Coll Life & Environm Sci, Shanghai, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
Huang, Ju
Zhang, Qian
论文数: 0引用数: 0
h-index: 0
机构:
East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
Zhang, Qian
Cui, Yi
论文数: 0引用数: 0
h-index: 0
机构:
East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R ChinaXiamen Univ, Med Coll, Dept Neurosurg, Affiliated Hosp 1, Xiamen, Peoples R China
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Pan, Zhaoping
Li, Xiang
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Li, Xiang
Wang, Yujia
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Wang, Yujia
Jiang, Qinglin
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Med Coll, Sch Pharm, Chengdu 610500, Peoples R China
Chengdu Med Coll, Sichuan Prov Coll Key Lab Struct Specif Small Mol, Chengdu 610500, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Jiang, Qinglin
Jiang, Li
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Med Coll, Sch Pharm, Chengdu 610500, Peoples R China
Chengdu Med Coll, Sichuan Prov Coll Key Lab Struct Specif Small Mol, Chengdu 610500, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Jiang, Li
Zhang, Min
论文数: 0引用数: 0
h-index: 0
机构:
Chengdu Med Coll, Sch Pharm, Chengdu 610500, Peoples R China
Chengdu Med Coll, Sichuan Prov Coll Key Lab Struct Specif Small Mol, Chengdu 610500, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Zhang, Min
Zhang, Nan
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Zhang, Nan
Wu, Fengbo
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Wu, Fengbo
Liu, Bo
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Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Liu, Bo
He, Gu
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h-index: 0
机构:
Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Sichuan, Peoples R China
Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Yuan, Ling
Guo, Haolin
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Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Guo, Haolin
Li, Qinyang
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h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Li, Qinyang
Zhang, Han
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h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Zhang, Han
Xu, Mujian
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h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Xu, Mujian
Zhang, Weiming
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Zhang, Weiming
Zhang, Yanyang
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Zhang, Yanyang
Hua, Ming
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Hua, Ming
Lv, Lu
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Lv, Lu
Pan, Bingcai
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h-index: 0
机构:
Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R ChinaNanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China
机构:
Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung, TaiwanKaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Chuang, Kai-Ting
Wang, Shen-Nien
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung, Taiwan
Kaohsiung Med Univ Hosp, Coll Med, Dept Surg, Kaohsiung, Taiwan
Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung, TaiwanKaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Wang, Shen-Nien
Hsu, Shih-Hsien
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, TaiwanKaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
Hsu, Shih-Hsien
Wang, Li-Ting
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Normal Univ, Dept Life Sci, Taipei, Taiwan
Kaohsiung Med Univ, Ctr Appl Genom, Kaohsiung, TaiwanKaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan