Lithium alkoxide-promoted Michael reaction between silyl enolates and α,β-unsaturated carbonyl compounds

被引：25
作者：
Mukaiyama, T
Tozawa, T
Fujisawa, H
机构：
[1] Kitasato Inst, TCI, Ctr Basic Res, Kita Ku, Tokyo 1140003, Japan
[2] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan
来源：
CHEMISTRY LETTERS | 2004年 / 33卷 / 11期
关键词：
D O I：
10.1246/cl.2004.1410
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Michael reaction between silyl enolates and alpha,beta-unsaturated carbonyl compounds by using a catalytic amount of Lewis base such as lithium alkoxide in DMF proceeds smoothly to afford the corresponding Michael-adducts in good yields with moderate to high diastereoselectivities. This reaction can be reasonably explained by considering an alkoxide anion-initiated autocatalytic process.
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页码：1410 / 1411
页数：2
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