SOX13 regulates cancer stem-like properties and tumorigenicity in hepatocellular carcinoma cells

被引:2
|
作者
Jiao, Hui [1 ]
Fang, Fei [1 ]
Fang, Ting [1 ]
You, Yuting [1 ]
Feng, Min [1 ]
Wang, Xiaomin [1 ]
Yin, Zhenyu [1 ]
Zhao, Wenxiu [1 ]
机构
[1] Xiamen Univ, Fujian Prov Key Lab Chron Liver Dis & Hepatocellu, Xiamen Translat Med Key Lab Digest Tumor, Zhongshan Hosp, Xiamen 361004, Fujian, Peoples R China
来源
AMERICAN JOURNAL OF CANCER RESEARCH | 2021年 / 11卷 / 03期
关键词
SOX13; hepatocellular carcinoma; tumorigenicity; TAZ; TUMOR-INITIATING CELLS; SELF-RENEWAL; EXPRESSION; TAZ; IDENTIFICATION; PROLIFERATION; PROMOTES; PREDICTS; CATENIN; GROWTH;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Sex-determining region Y (SRY)-related high mobility group (HMG) box (SOX) proteins are pivotal transcriptional factors that play essential roles in embryonic development, cell fate decisions and cancer development. The molecular mechanism of SOX13, a member of the SOX family, in hepatocellular carcinoma (HCC) remains largely unknown. In the current study, we found that HCC cells were able to form spheroids in serum-free suspension culture and that SOX13 expression was upregulated in spheroids enriched for cancer stem cells (CSCs). Inhibition of SOX13 in HCC-LM3 and MHCC-97H cells decreased the expression of stemness-related genes; attenuated spheroid formation, anchor-dependent and anchor-independent cell proliferation and tumorigenicity; and enhanced sensitivity to drug treatment. Furthermore, based on analysis of TCGA dataset, the results indicated that SOX13 expression was obviously upregulated and closely associated with poor prognosis in HCC patients. Moreover, SOX13 was correlated with TAZ and CD24 expression. These data strongly demonstrated that SOX13 is involved in maintaining cancer stem-like properties in HCC cells and plays a critical role in HCC development.
引用
收藏
页码:760 / 772
页数:13
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