ER-α variants and the cardiovascular effects of hormone replacement therapy

被引：29

作者：

Herrington, DM ^{[1
]}

Howard, TD ^{[1
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med Cardiol, Winston Salem, NC 27157 USA

来源：

PHARMACOGENOMICS | 2003年 / 4卷 / 03期

关键词：

estrogen receptor polymorphisms; HDL-cholesterol; hormone therapy;

D O I：

10.1517/phgs.4.3.269.22686

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There is an accumulating body of evidence linking estrogen receptor-alpha (ER-alpha) gene polymorphisms with variation in cardiovascular risk factors or disease. The ER-alpha IVS1-397 T/C (Pvull), IVS1-351 A/C (Xbal) and the promoter region TA repeat polymorphisms have received the most attention. If ER-alpha genetic variants identify women at high risk for cardiovascular events, this information could be used to improve clinical decisions regarding the use of hormone replacement therapy (HRT). More detailed haplotype and genome-wide studies of many of the major HRT clinical trial cohorts are currently underway and these efforts promise to clarify many outstanding issues concerning estrogen action and cardiovascular disease.

引用

页码：269 / 277

页数：9

共 39 条

[1]

ANDERSEN TI, 1994, HUM GENET, V94, P665

[2] AN ESTROGEN-RECEPTOR GENETIC-POLYMORPHISM AND THE RISK OF PRIMARY AND SECONDARY RECURRENT SPONTANEOUS-ABORTION [J].

BERKOWITZ, GS ;

STONE, JL ;

LEHRER, SP ;

MARCUS, M ;

LAPINSKI, RH ;

SCHACHTER, BS .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1994, 171 (06) :1579-1584

[3] Interaction of hemostatic genetics with hormone therapy - New insights to explain arterial thrombosis in postmenopausal women [J].

Braunstein, JB ;

Kershner, DW ;

Bray, P ;

Gerstenblith, G ;

Schulman, SP ;

Post, WS ;

Blumenthal, RS .

CHEST, 2002, 121 (03) :906-920

[4] Effects of 17 beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression [J].

CaulinGlaser, T ;

Watson, CA ;

Pardi, R ;

Bender, JR .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (01) :36-42

[5] The human obesity gene map: The 1997 update [J].

Chagnon, YC ;

Perusse, L ;

Bouchard, C .

OBESITY RESEARCH, 1998, 6 (01) :76-92

[6] Estrogens and the vascular endothelium [J].

Cid, MC ;

Schnaper, HW ;

Kleinman, HK .

NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES II, PROCEEDINGS, 2002, 966 :143-157

[7] A study of hormone replacement therapy in postmenopausal women with ischaemic heart disease: the Papworth HRT Atherosclerosis Study [J].

Clarke, SC ;

Kelleher, J ;

Lloyd-Jones, H ;

Slack, M ;

Schofield, PM .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2002, 109 (09) :1056-1062

[8] Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes [J].

Deng, HW ;

Li, J ;

Li, JL ;

Johnson, M ;

Gong, G ;

Davis, KM ;

Recker, RR .

HUMAN GENETICS, 1998, 103 (05) :576-585

[9] Association of estrogen receptor-α genotypes with body mass index in normal healthy postmenopausal Caucasian women [J].

Deng, HW ;

Li, J ;

Li, JL ;

Dowd, R ;

Davies, KM ;

Johnson, M ;

Gong, G ;

Deng, HY ;

Recker, RR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (08) :2748-2751

[10] Differentially expressed messenger RNA isoforms of the human estrogen receptor-α gene are generated by alternative splicing and promoter usage [J].

Flouriot, G ;

Griffin, C ;

Kenealy, M ;

Sonntag-Buck, V ;

Gannon, F .

MOLECULAR ENDOCRINOLOGY, 1998, 12 (12) :1939-1954

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