Procedures for and possible mechanisms of Pd-catalyzed allylations of primary and secondary amines with allylic alcohols

被引：165

作者：

Muzart, Jacques ^{[1
]}

机构：

[1] Univ Reims, CNRS, Unit Mix Rech, F-51687 Reims, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 2007卷 / 19期

关键词：

allylic alcohol; allylic amine; allylation; palladium; promoter; reaction mechanisms; DIPHOSPHINIDENECYCLOBUTENE-COORDINATED PALLADIUM; PALLADIUM(0)-CATALYZED ALLYLATION; (PI-ALLYL)PALLADIUM COMPLEXES; TANDEM ALLYLATION; 3-STEP SYNTHESIS; C-O; ANILINES; AMINATION; ACID; ALKYLATION;

D O I：

10.1002/ejoc.200601050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review describes the different Pd-catalyzed methods that afford allylic amines from intermolecular reactions between allylic alcohols and amines and, with personal comments, the mechanisms that have been proposed. Allylic amines are an important class of compounds, while a wide structural variety of allylic alcohols are commercially available and are abundant in nature. The advantages of the use of allylic alcohols over that of their derivatives such as allylic esters or carbonates are the high atom efficiency and the formation only of water as the by-product.

引用

页码：3077 / 3089

页数：13

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