Toward adaptive deep brain stimulation for dystonia

被引：33

作者：

Pina-Fuentes, Dan ^{[1
,2
]}

Beudel, Martijn ^{[2
,3
]}

Little, Simon ^{[4
]}

van Zijl, Jonathan ^{[2
]}

Elting, Jan Willem ^{[2
]}

Oterdoom, D. L. Marinus ^{[1
]}

van Egmond, Martje E. ^{[2
]}

van Dijk, J. Marc C. ^{[1
]}

Tijssen, Marina A. J. ^{[2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosurg, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands

[3] Isala Klin, Dept Neurol, Zwolle, Netherlands

[4] UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, Queen Sq, London, England

来源：

NEUROSURGICAL FOCUS | 2018年 / 45卷 / 02期

基金：

英国惠康基金;

关键词：

adaptive deep brain stimulation; dystonia; local field potentials; electromyography; low-frequency oscillations; LOCAL-FIELD POTENTIALS; GLOBUS-PALLIDUS INTERNUS; PARKINSONS-DISEASE; OSCILLATORY ACTIVITY; CERVICAL DYSTONIA; SUBTHALAMIC NUCLEUS; SEGMENTAL DYSTONIA; MOVEMENT-DISORDERS; MYOCLONUS-DYSTONIA; SUSTAINED RELIEF;

D O I：

10.3171/2018.5.FOCUS18155

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The presence of abnormal neural oscillations within the cortico-basal ganglia-thalamo-cortical (CBGTC) network has emerged as one of the current principal theories to explain the pathophysiology of movement disorders. In theory, these oscillations can be used as biomarkers and thereby serve as a feedback signal to control the delivery of deep brain stimulation (DBS). This new form of DBS, dependent on different characteristics of pathological oscillations, is called adaptive DBS (aDBS), and it has already been applied in patients with Parkinson's disease. In this review, the authors summarize the scientific research to date on pathological oscillations in dystonia and address potential biomarkers that might be used as a feedback signal for controlling aDBS in patients with dystonia.

引用

页数：8

共 75 条

[1]

Agnesi Filippo, 2013, Handb Clin Neurol, V116, P39, DOI 10.1016/B978-0-444-53497-2.00004-8

[2] Phenomenology and classification of dystonia: A consensus update [J].