Serum interleukin 18 and tumour necrosis factor-α levels are increased in Behcet's disease

被引：73

作者：

Oztas, MO

Onder, M

Gurer, MA

Bukan, N

Sancak, B

机构：

[1] Gazi Univ, Fac Med, Dept Dermatol, Ankara, Turkey

[2] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkey

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2005年 / 30卷 / 01期

关键词：

D O I：

10.1111/j.1365-2230.2004.01684.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Inflammation in Behcet's disease is thought to be mediated by cytokines derived from T-helper type 1 (Th1) lymphocytes. In this study, we tried to determine serum interleukin (IL)-18 and tumour necrosis factor (TNF)-alpha levels of patients with Behcet's disease. Twenty-seven patients with active Behcet's disease, and 20 healthy control subjects were included in this study. Differences between mean serum IL-18 and TNF-alpha level of patients with Behcet's disease were significantly increased when compared with the control group. A significant correlation was found between serum IL-18 and TNF-alpha levels of Behcet patients (r(s) = 0.627, P < 0.0001). IL-18 and TNF-alpha levels may be related to disease pathogenesis. Increased levels of IL-18 also support Th1 predominance in Behcet's disease.

引用

页码：61 / 63

页数：3

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