Visible Light-Induced Photocatalytic C-H Perfluoroalkylation of Quinoxalinones under Aerobic Oxidation Condition

被引：104

作者：

Wei, Zhenjiang ^{[1
]}

Qi, Sijia ^{[1
]}

Xu, Yanhao ^{[1
]}

Liu, Hao ^{[1
]}

Wu, Junzhen ^{[1
]}

Li, Hongshuang ^{[1
]}

Xia, Chengcai ^{[1
]}

Duan, Guiyun ^{[1
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, Tai An 271000, Shandong, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 23期

关键词：

visible light; photocatalysis; quinoxalinones; C-H perfluoroalkylation; additive free; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION; BOND TRIFLUOROMETHYLATION; RADICAL CYCLIZATION; UNACTIVATED ALKENES; ARYLDIAZONIUM SALTS; HIGHLY POTENT; BASE-FREE; QUINOXALIN-2(1H)-ONES; MILD; ACCESS;

D O I：

10.1002/adsc.201900885

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient approach using a photocatalytic strategy for C-H perfluoroalkylation of quinoxalinones under aerobic oxidation condition has been developed. Such transformation employs readily available sodium perfluoroalkanesulfinates as perfluoroalkylation reagents and demonstrates good functional group compatibility, affording corresponding products in moderate to good yields. Compared with previous procedures, this protocol uses oxygen as oxidant, and avoids the use of external additive. A radical mechanism is involved in this perfluoroalkylation reaction.

引用

页码：5490 / 5498

页数：9

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