The evaluation of serum N-terminal prohormone brain-type natriuretic peptide, troponin-I, and high-sensitivity C-reactive protein levels in children with congenital heart disease

被引:13
作者
Uner, A. [1 ]
Dogan, M. [2 ]
Ay, M. [2 ]
Acar, C. [1 ]
机构
[1] Yuzuncu Yil Univ, Sch Med, Div Pediat Cardiol, Dept Pediat, TR-65100 Van, Turkey
[2] Yuzuncu Yil Univ, Sch Med, Dept Pediat, TR-65100 Van, Turkey
关键词
Congenital heart disease; NT-proBNP; cTnI; Hs-CRP; HYPOXIA; UTILITY; ATRIAL; BNP;
D O I
10.1177/0960327113514097
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Although advanced diagnostic and treatment methods are available, congenital heart disease (CHD) holds an important place among the causes of death within the first year of age. Therefore, several prognostic factors are needed for diagnosis and monitoring of these patients. In this study, which includes 66 CHD patients and 38 healthy control children, serum cardiac troponin-I (cTnI), high-sensitivity C-reactive protein (Hs-CRP), and N-terminal prohormone brain-type natriuretic peptide (NT-proBNP) levels were analyzed for their prognostics values. The patient groups were categorized and then evaluated as cyanotic (n = 16), acyanotic (n = 50), symptomatic (n = 23), asymptomatic (n = 43), and isolated ventricular septal defect (VSD)-isolated atrial septal defect (ASD) groups. Cyanotic group was statistically compared with acyanotic group, symptomatic group with asymptomatic group, and VSD group with ASD group. Between the cyanotic, acyanotic, and control groups; between symptomatic and asymptomatic groups; and between the VSD and ASD groups, significant difference was not showed for age (p > 0.05). NT-proBNP was found to be significantly higher in the cyanotic group than acyanotic and control group, in the symptomatic group than asymptomatic group; and in the patient group than healthy control group (p < 0.05). Between the groups of VSD and ASD, significant difference was not showed (p > 0.05). The same comparison results for TnI and Hs-CRP were not significant (p > 0.05). TnI and Hs-CRP were only found significantly higher in the patient group than healthy control group (p < 0.05). Eventually, we think that NT-proBNP, Hs-CRP, and TnI might be used for clinical management and estimation of outcome of these disorders in the future and these also might be able to modify existing strategies, but much more studies are needed.
引用
收藏
页码:1158 / 1166
页数:9
相关论文
共 30 条
  • [1] Bernstein D., 2008, PEDIAT NELSON KITABI, P1499
  • [2] Burtis CA, 1999, TIETZ TXB CLIN CHEM, P1194
  • [3] B-type natriuretic peptide levels in congenital heart disease
    Cowley, CG
    Bradley, JD
    Shaddy, RE
    [J]. PEDIATRIC CARDIOLOGY, 2004, 25 (04) : 336 - 340
  • [4] B-type natriuretic peptide in pediatrics
    Davis, Gershwin K.
    Barnforth, Fiona
    Sarpal, Amrita
    Dicke, Frank
    Rabi, Yacov
    Lyon, Martha E.
    [J]. CLINICAL BIOCHEMISTRY, 2006, 39 (06) : 600 - 605
  • [5] Demirol HA., 2011, THESIS FIRAT U TIP F
  • [6] The Usefulness of Brain Natriuretic Peptide in Complex Congenital Heart Disease A Systematic Review
    Eindhoven, Jannet A.
    van den Bosch, Annemien E.
    Jansen, Philip R.
    Boersma, Eric
    Roos-Hesselink, Jolien W.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (21) : 2140 - 2149
  • [7] Flanagan MF, 1999, NEONATOLOGY PATHOPHY, P577
  • [8] Assay for measurement of intact B-type natriuretic peptide prohormone in blood
    Giuliani, Isabelle
    Rieunier, Francois
    Larue, Catherine
    Delagneau, Jean-Franois
    Granier, Claude
    Pau, Bernard
    Ferriere, Marc
    Saussine, Max
    Cristol, Jean-Paul
    Dupuy, Anne-Marie
    Merigeon, Emmanuel
    Merle, Delphine
    Villard, Sylvie
    [J]. CLINICAL CHEMISTRY, 2006, 52 (06) : 1054 - 1061
  • [9] Graham Jr TP, 1995, MOSS ADAMS HEART DIS, P724
  • [10] Utility of N-terminal pro-B-type natriuretic peptide to differentiate cardiac diseases from noncardiac diseases in young pediatric patients
    Hammerer-Lercher, Angelika
    Geiger, Ralf
    Mair, Johannes
    Url, Christoph
    Tulzer, Gerald
    Lechner, Evelyn
    Puschendorf, Bernd
    Sommer, Rudolf
    [J]. CLINICAL CHEMISTRY, 2006, 52 (07) : 1415 - 1419