Blood Glucose Regulation in Patients with Type 1 Diabetes Mellitus: A Robust MRAC Approach

被引：1

作者：

Franco, Roberto ^{[1
]}

Rios, Hector ^{[1
,3
]}

de Loza, Alejandra Ferreira ^{[2
,3
]}

Efimov, Denis ^{[4
]}

Cassany, Louis ^{[5
]}

Gucik-Derigny, David ^{[5
]}

Cieslak, Jerome ^{[5
]}

Henry, David ^{[5
]}

机构：

[1] Tecnol Nacl Mexico IT La Laguna, Div Estudios Posgrad & Invest, Torreon 27000, Coahuila, Mexico

[2] Inst Politecn Nacl CITEDI, Tijuana 22435, Baja California, Mexico

[3] Catedras CONACYT, Ciudad De Mexico 03940, Mexico

[4] Informat Technol Mech & Opt Univ, Dept Control Syst & Informat, St Petersburg 197101, Russia

[5] Univ Bordeaux, CNRS, Bordeaux INP, IMS,UMR 5218, F-33400 Talence, France

来源：

2021 60TH IEEE CONFERENCE ON DECISION AND CONTROL (CDC) | 2021年

关键词：

Diabetes Mellitus Type 1; Blood Glucose Regulation; Adaptive Control; ARTIFICIAL PANCREAS; ADAPTIVE-CONTROL; SYSTEMS;

D O I：

10.1109/CDC45484.2021.9683408

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

This paper deals with the problem of robust blood glucose regulation in critically ill patients affected by type 1 diabetes mellitus. The blood glucose measurement and insulin infusion are intravenous. The proposed algorithm regulates blood glucose and keeps it in the normoglycemia range, i.e., 70-180 mg/dl. To this aim, a control law is proposed based on a Nonlinear Model Reference Adaptive Control approach. The algorithm is composed of nonlinear adaptive gains that ensure convergence to zero of the regulation error. The approach is validated in the UVA/Padova metabolic simulator for ten in silico adult patients with unannounced meals. The results perform well and have minimal risk of hyperglycemic and hypoglycemic events.

引用

页码：661 / 666

页数：6

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