Immunodietica: A data-driven approach to investigate interactions between diet and autoimmune disorders

被引：14

作者：

Gershteyn, Iosif M. ^{[1
,2
]}

Ferreira, Leonardo M. R. ^{[1
,3
,4
]}

机构：

[1] Ajax Biomed Fdn, Newton, MA 02461 USA

[2] ImmuVia LLC, Waltham, MA 02451 USA

[3] Univ Calif San Francisco, Dept Surg, Transplantat Res Lab, San Francisco, CA USA

[4] Univ Calif San Francisco, Diabet Ctr, Sean N Parker Autoimmun Res Lab, San Francisco, CA 94143 USA

来源：

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY | 2019年 / 1卷

关键词：

Autoimmunity; Diet; Epitopes; Cross-reactivity; Gershteyn-Ferreira index;

D O I：

10.1016/j.jtauto.2019.100003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmunity is on the rise around the globe. Diet has been proposed as a risk factor for autoimmunity and shown to modulate the severity of several autoimmune disorders. Yet, the interaction between diet and auto-immunity in humans remains largely unstudied. Here, we systematically interrogated commonly consumed animals and plants for peptide epitopes previously implicated in human autoimmune disease. A total of fourteen species investigated could be divided into three broad categories regarding their content in human autoimmune epitopes, which we represented using a new metric, the Gershteyn-Ferreira index (GF index). Strikingly, pig contains a disproportionately high number of unique autoimmune epitopes compared to all other species analyzed. This work uncovers a potential new link between pork consumption and autoimmunity in humans and lays the foundation for future studies on the impact of diet on the pathogenesis and progression of autoimmune disorders.

引用

页数：7

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