CsF in organic synthesis. The first and convenient synthesis of enantiopure bisoprolol by use of glycidyl nosylate

被引：16

作者：

Kitaori, K

Furukawa, Y

Yoshimoto, H

Otera, J

机构：

[1] Daiso Co Ltd, Res Labs, Amgasaki, Hyogo 6600842, Japan

[2] Okayama Univ Sci, Dept Appl Chem, Okayama 7000005, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(98)00452-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective substitution of glycidyl nosylate with phenols is catalyzed by CsF in the presence of K2CO3 in DMF; this reaction enables the first and convenient synthesis of enantiopure bisoprolol. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：3173 / 3176

页数：4

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