Studies towards the stereoselective total synthesis of Gliomasolide A

被引：1
|
作者：
Kare, Nagaraju [1 ,2 ]
Kundoor, Govinda Reddy [1 ]
Palakodety, Radha Krishna [1 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Organ Synth & Proc Chem Div, Hyderabad 500007, Andhra Pradesh, India
[2] Acad Sci & Innovat Res AcSIR, New Delhi 110025, India
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 48期
关键词：
Asymmetric Keck and Brown's allylations; Sharpless kinetic resolution; Cross-metathesis; Ring-closing metathesis;
D O I：
10.1016/j.tetlet.2019.151169
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first synthetic approach towards the Gliomasolide A is described in 15 linear steps with 4% overall yield. The key steps in this approach are RCM protocol for the construction of 14-member macrolide, a Sharpless kinetic resolution, Keck and Brown's allylations for the installation of desired stereocenters. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：3
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