Synthesis and antimicrobial activity of some new 1-methyl [(N-alkyl phthalyl)-benzimidazolo]-3'-chloro-4'-substituted azetidin-2-ones

被引：0

作者：

Parmar, Shipra ^{[1
]}

Sah, Pramilla ^{[1
]}

机构：

[1] Jai Narain Vyas Univ, Dept Chem, Jodhpur 342005, Rajasthan, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 16卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Alkyl phthalyl benzimidazoles (IV) were synthesized by treating o-phenylene diamine with N-phthalyl substituted amino acids (III). These were subjected to Mannich reaction using formaldehyde and ammonium chloride giving the Mannich base i.e. N-alkyl phthalyl-1-amino methyl benzimidazoles (V). Reaction of V with appropriate aromatic aldehydes under anhyd conditions yielded the Schiff's bases (VI). Cyclization of VI with chloroacetyl chloride in 1,4-dioxan in presence of triethyl amine gave 1-methyl [(N-alkyl phthalyl)-benzimidazolo]3'-chloro-4'-substituted azetidin-2-onesVII. The compounds were characterized by means of mass, IR, PMR and elemental analysis. Some of the azetidinones have shown promising antimicrobial activity.

引用

页码：367 / 370

页数：4

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