Exploring the Role and Potential of Probiotics in the Field of Mental Health: Major Depressive Disorder

被引:65
作者
Johnson, Dinyadarshini [1 ]
Thurairajasingam, Sivakumar [2 ]
Letchumanan, Vengadesh [1 ]
Chan, Kok-Gan [3 ,4 ]
Lee, Learn-Han [1 ]
机构
[1] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Novel Bacteria & Drug Discovery Res Grp NBDD, Microbiome & Bioresource Res Strength MBRS, Bandar Sunway 47500, Malaysia
[2] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Clin Sch Johor Bahru, Johor Baharu 80100, Malaysia
[3] Univ Malaya, Inst Biol Sci, Div Genet & Mol Biol, Fac Sci, Kuala Lumpur 50603, Malaysia
[4] Jiangsu Univ, Int Genome Ctr, Zhenjiang 212013, Jiangsu, Peoples R China
关键词
probiotic; microbiota; major depressive disorder; epigenetic; antidepressant; INDUCED INTERLEUKIN-8 PRODUCTION; LACTOBACILLUS-PLANTARUM PS128; IRRITABLE-BOWEL-SYNDROME; GAMMA-AMINOBUTYRIC-ACID; GUT MICROBIOTA; DOUBLE-BLIND; KYNURENINE PATHWAY; SODIUM-BUTYRATE; STRESS; BEHAVIOR;
D O I
10.3390/nu13051728
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The field of probiotic has been exponentially expanding over the recent decades with a more therapeutic-centered research. Probiotics mediated microbiota modulation within the microbiota-gut-brain axis (MGBA) have been proven to be beneficial in various health domains through pre-clinical and clinical studies. In the context of mental health, although probiotic research is still in its infancy stage, the promising role and potential of probiotics in various mental disorders demonstrated via in-vivo and in-vitro studies have laid a strong foundation for translating preclinical models to humans. The exploration of the therapeutic role and potential of probiotics in major depressive disorder (MDD) is an extremely noteworthy field of research. The possible etio-pathological mechanisms of depression involving inflammation, neurotransmitters, the hypothalamic-pituitary-adrenal (HPA) axis and epigenetic mechanisms potentially benefit from probiotic intervention. Probiotics, both as an adjunct to antidepressants or a stand-alone intervention, have a beneficial role and potential in mitigating anti-depressive effects, and confers some advantages compared to conventional treatments of depression using anti-depressants.
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页数:18
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