Lynch syndrome; towards more personalized management?

被引：13

作者：

Llach, Joan ^{[1
]}

Pellise, Maria ^{[1
]}

Monahan, Kevin ^{[2
,3
,4
]}

机构：

[1] Univ Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Hosp Clin Barcelona, Dept Gastroenterol,Ctr Invest Biomed Red Enfermed, Barcelona, Spain

[2] Imperial Coll London, London HA1 3UJ, England

[3] St Marks Ctr Familial Intestinal Canc, Lynch Syndrome & Family Canc Clin, London HA1 3UJ, England

[4] St Marks, Polyposis Registry, London HA1 3UJ, England

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2022年 / 58-59卷

关键词：

Lynch syndrome; Colorectal cancer; Endometrial cancer; Colonoscopy; Prevention; HEREDITARY COLORECTAL-CANCER; RISK; NIVOLUMAB; COLECTOMY; ADENOMAS; FAMILIES; CARRIERS; ASPIRIN; TUMORS;

D O I：

10.1016/j.bpg.2022.101790

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Lynch syndrome is the most common inherited cause of colorectal (lifetime risk up to 70%) and endometrial cancer. The diagnosis of Lynch syndrome facilitates preventive measures aimed at reducing the incidence and mortality of cancer. Colonoscopic surveillance for colorectal cancer, aspirin, and prophylactic hysterectomy and bilateral salpo-oopherectomy for endometrial and/or ovarian cancer have demonstrated to effectively reduce cancer mortality in this population. However, the lifetime risk of each cancer in people with Lynch syndrome is gene-specific and may be modified by environmental factors. Furthermore, the benefits of surveillance strategies need to be balanced against the risk of over-diagnosis and be supported by evidence of improved outcomes from cancer diagnosis in surveillance. Therefore, people with Lynch syndrome may benefit from a personalized management approach.

引用

页数：7

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