Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

被引：26

作者：

Shi, Wei ^{[1
]}

Duan, Yuejiao ^{[1
]}

Qian, Yu ^{[1
]}

Li, Ming ^{[1
]}

Yang, Liping ^{[1
]}

Hu, Wenhao ^{[1
]}

机构：

[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 12期

关键词：

PDF inhibitor; Drug-resistant bacteria; Antibiotics; ACTINONIN;

D O I：

10.1016/j.bmcl.2010.04.123

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives are reported. The antibacterial activities of these derivatives were evaluated, and some of these derivatives showed better in vitro antibacterial activity than existing drugs, including penicillin, ciprofloxacin, vancomycin, and linezolid. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3592 / 3595

页数：4

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